Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Department of Rehabilitation Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Mol Med Rep. 2021 Apr;23(4). doi: 10.3892/mmr.2021.11874. Epub 2021 Feb 4.
Heat shock protein 32 (Hsp32), also known as heme oxygenase‑1 (HO‑1), is an enzyme that exists in microsomes. HO‑1 can be induced by a variety of stimuli, including heavy metals, heat shock, inflammatory stimuli, heme and its derivatives, stress, hypoxia, and biological hormones. HO‑1 is the rate‑limiting enzyme of heme catabolism, which splits heme into biliverdin, carbon monoxide (CO) and iron. The metabolites of HO‑1 have anti‑inflammatory and anti‑oxidant effects, and provide protection to the cardiovascular system and transplanted organs. This review summarizes the biological characteristics of HO‑1 and the functional significance of its products, and specifically elaborates on its protective effect on skin flaps. HO‑1 improves the survival rate of ischemic skin flaps through anti‑inflammatory, anti‑oxidant and vasodilatory effects of enzymatic reaction products. In particular, this review focuses on the role of carbon monoxide (CO), one of the primary metabolites of HO‑1, in flap survival and discusses the feasibility and existing challenges of HO‑1 in flap surgery.
热休克蛋白 32（Hsp32），又称血红素加氧酶 1（HO-1），是一种存在于微粒体中的酶。HO-1 可被多种刺激诱导，包括重金属、热休克、炎症刺激、血红素及其衍生物、应激、缺氧和生物激素。HO-1 是血红素分解代谢的限速酶，可将血红素分解为胆绿素、一氧化碳（CO）和铁。HO-1 的代谢产物具有抗炎和抗氧化作用，并为心血管系统和移植器官提供保护。本综述总结了 HO-1 的生物学特性及其产物的功能意义，并特别阐述了其对皮瓣的保护作用。HO-1 通过酶反应产物的抗炎、抗氧化和血管扩张作用提高缺血皮瓣的存活率。特别是，本综述重点关注 HO-1 的主要代谢产物之一一氧化碳（CO）在皮瓣存活中的作用，并讨论了 HO-1 在皮瓣手术中的可行性和存在的挑战。
