Klinik für Neurologie, Knappschaftskrankenhaus Dortmund, Klinikum Westfalen, 44309, Dortmund, Germany.
Fakultät für Gesundheit, Department für Humanmedizin, Universität Witten/Herdecke, 58455, Witten, Germany.
J Neurol. 2021 Sep;268(9):3125-3128. doi: 10.1007/s00415-021-10428-6. Epub 2021 Feb 4.
We report on a patient with refractory Myasthenia gravis with acetylcholine receptor antibodies with two prior myasthenic crises suffering from COVID-19 with rapid evolving weakness and respiratory failure. Respiratory failure developed and prolonged mechanical ventilation was necessary. After plasmapheresis, residual, severe generalized and bulbar weakness persisted. Complement inhibition with eculizumab was, therefore, introduced and lead to rapid recovery. In refractory myasthenic crisis individualised therapies could be successful.
我们报告了一例患有乙酰胆碱受体抗体难治性重症肌无力的患者，该患者患有 COVID-19，出现肌无力迅速进展和呼吸衰竭。呼吸衰竭发展，需要长时间机械通气。血浆置换后，仍存在严重的全身和球部肌无力。因此，给予补体抑制药物依库珠单抗治疗，并迅速恢复。在难治性重症肌无力危象中，个体化治疗可能是成功的。
