Gerlag P G, van Rooy M J, Booij A, van Dam F E, op de Coul A A
Clin Neurol Neurosurg. 1980;82(4):237-43. doi: 10.1016/0303-8467(80)90015-3.
A 27-year-old man with myasthenia gravis developed a severe myasthenic crisis with respiratory insufficiency. In spite of high iv doses of pyridostigminebromide and corticosteroids, mechanical ventilation remained necessary. Treatment with plasma exchange grossly decreased the serum level of antibodies against acetylcholine receptor protein and caused an immediate clinical improvement. The respiratory assistance could be terminated and muscle strength increased substantially. Plasmapheresis seemed to be of definite benefit in the treatment of this acute crisis of myasthenia gravis.
一名27岁的重症肌无力男性患者发生了严重的肌无力危象并伴有呼吸功能不全。尽管静脉注射了大剂量的溴吡斯的明和皮质类固醇，但仍需要机械通气。血浆置换治疗使抗乙酰胆碱受体蛋白抗体的血清水平大幅下降，并立即带来了临床改善。呼吸辅助可以终止，肌肉力量也大幅增加。血浆置换在治疗重症肌无力的这一急性危象中似乎有明确的益处。
