Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China.
College of Stomatology, Xi'an Jiaotong University, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi'an, Shaanxi, People's Republic of China.
J Cardiovasc Pharmacol. 2021 Feb 1;77(2):170-181. doi: 10.1097/FJC.0000000000000953.
Oxidative stress, the renin-angiotensin system (RAS), and inflammation are some of the mechanisms involved in the pathogenesis of hypertension. The aim of this study is to examine the protective effect of the chronic administration of astaxanthin, which is extracted from the shell of crabs and shrimps, into hypothalamic paraventricular nucleus (PVN) in spontaneously hypertensive rats. Animals were randomly assigned to 2 groups and treated with bilateral PVN infusion of astaxanthin or vehicle (artificial cerebrospinal fluid) through osmotic minipumps (Alzet Osmotic Pumps, Model 2004, 0.25 μL/h) for 4 weeks. Spontaneously hypertensive rats had higher mean arterial pressure and plasma level of norepinephrine and proinflammatory cytokine; higher PVN levels of reactive oxygen species, NOX2, NOX4, IL-1β, IL-6, ACE, and AT1-R; and lower PVN levels of IL-10 and Cu/Zn SOD, Mn SOD, ACE2, and Mas receptors than Wistar-Kyoto rats. Our data showed that chronic administration of astaxanthin into PVN attenuated the overexpression of reactive oxygen species, NOX2, NOX4, inflammatory cytokines, and components of RAS within the PVN and suppressed hypertension. The present results revealed that astaxanthin played a role in the brain. Our findings demonstrated that astaxanthin had protective effect on hypertension by improving the balance between inflammatory cytokines and components of RAS.
氧化应激、肾素-血管紧张素系统（RAS）和炎症是高血压发病机制中的一些机制。本研究旨在探讨慢性给予虾青素（从蟹和虾的壳中提取）对自发性高血压大鼠下丘脑室旁核（PVN）的保护作用。动物被随机分为 2 组，并通过渗透微型泵（Alzet Osmotic Pumps，Model 2004，0.25 μL/h）向 PVN 双侧输注虾青素或载体（人工脑脊液）4 周。自发性高血压大鼠的平均动脉压和血浆去甲肾上腺素和促炎细胞因子水平较高；PVN 中活性氧、NOX2、NOX4、IL-1β、IL-6、ACE 和 AT1-R 的水平较高；PVN 中 IL-10 和 Cu/Zn SOD、Mn SOD、ACE2 和 Mas 受体的水平较低。与 Wistar-Kyoto 大鼠相比。我们的数据表明，慢性给予 PVN 虾青素可减轻 PVN 内活性氧、NOX2、NOX4、促炎细胞因子和 RAS 成分的过度表达，并抑制高血压。目前的结果表明，虾青素在大脑中发挥作用。我们的研究结果表明，虾青素通过改善炎症细胞因子和 RAS 成分之间的平衡对高血压具有保护作用。
