Gao Chunhao, Gong Nengyun, Chen Fangtian, Hu Shiran, Zhou Qingxin, Gao Xiang
College of Life Sciences, Qingdao University, Qingdao 266071, China.
Department of Marine Technology, Rizhao Polytechnic, Shandong Engineering and Technology Research Center for Marine Crustacean Resources Comprehensive Utilization, Shandong Engineering Research Center for Efficient Utilization Technology of Marine Food Resources, Rizhao Key Laboratory of Efficient Utilization of Marine Food Resources, Rizhao 276826, China.
Mar Drugs. 2024 Dec 27;23(1):9. doi: 10.3390/md23010009.
Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. Astaxanthin (AST), a carotenoid found in various marine organisms, exhibits exceptional antioxidant properties and holds great promise as a natural compound that improves MS. This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. These mechanisms primarily involve regulating signal transduction, transport, or metabolic pathways within the body, as well as influencing intestinal microbiota and metabolites, thereby exerting positive effects on metabolism and inhibiting the occurrence of MS. This review emphasizes the potential efficacy of AST in managing MS. However, more studies are needed to confirm the clinical effect of AST on MS and reveal potential molecular mechanisms.
代谢综合征（MS）是一组复杂的代谢紊乱症候群，主要特征为肥胖、胰岛素抵抗、高血糖、血脂异常、高血压和高尿酸血症。饮食和功能性成分在寻求预防和改善MS的非药物策略中起着关键作用。虾青素（AST）是一种存在于多种海洋生物中的类胡萝卜素，具有卓越的抗氧化特性，作为一种改善MS的天然化合物具有巨大潜力。本文介绍了AST的基本特性，包括其吸收和代谢途径以及各种异构体。最重要的是，我们全面综述了AST对改善MS主要成分的作用及机制。这些机制主要涉及调节体内信号转导、转运或代谢途径，以及影响肠道微生物群和代谢产物，从而对代谢产生积极影响并抑制MS的发生。本综述强调了AST在管理MS方面的潜在功效。然而，需要更多研究来证实AST对MS的临床效果并揭示潜在的分子机制。
