Department of Anesthesiology and Pain Medicine, Toronto Western Hospital, University of Health Network, University of Toronto, Toronto, ON, Canada.
Faculty of Sports Sciences, CETAPS EA 3832, University of Rouen.
J Neurosurg Anesthesiol. 2022 Oct 1;34(4):364-371. doi: 10.1097/ANA.0000000000000760. Epub 2021 Feb 2.
The trigeminocardiac reflex (TCR) is a well-recognized brainstem reflex that represents a unique interaction between the brain and the heart through the Vth and Xth cranial nerves and brainstem nuclei. The TCR has mainly been reported as an intraoperative phenomenon causing cardiovascular changes during skull-base surgeries. However, it is now appreciated that the TCR is implicated during non-neurosurgical procedures and in nonsurgical conditions, and its complex reflex pathways have been explored as potential therapeutic options in various neurological and cardiovascular diseases. This narrative review presents an in-depth overview of hypothetical and experimental models of the TCR phenomenon in relation to the Vth and Xth cranial nerves. In addition, primitive interactions between these 2 cranial nerves and their significance are highlighted. Finally, therapeutic models of the complex interactions of the TCR and areas for further research will be considered.
三叉心反射（TCR）是一种公认的脑干反射，通过第五和第十颅神经以及脑干核代表了大脑和心脏之间的独特相互作用。TCR 主要作为一种术中现象被报道，在颅底手术期间引起心血管变化。然而，现在人们已经认识到，TCR 与非神经外科手术过程和非手术情况有关，其复杂的反射途径已被探索作为各种神经和心血管疾病的潜在治疗选择。本综述深入介绍了 TCR 现象与第五和第十颅神经之间的假设和实验模型。此外，还强调了这两条颅神经之间的原始相互作用及其意义。最后，将考虑 TCR 复杂相互作用的治疗模型以及进一步研究的领域。
