在埃塞俄比亚东北部的一家医院住院的成年患者中，肾功能不全和蛋白尿的患病率及相关因素。
Prevalence and associated factors of impaired renal function and albuminuria among adult patients admitted to a hospital in Northeast Ethiopia.
机构信息
Department of Clinical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Department of Medical Laboratory Science, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
出版信息
PLoS One. 2021 Feb 4;16(2):e0246509. doi: 10.1371/journal.pone.0246509. eCollection 2021.
BACKGROUND
Chronic kidney disease (CKD) is increasingly common in hospitalized patients and is associated with increased risk for in-hospital morbidity and mortality. However, data regarding the prevalence of CKD in the African hospitalized patient population are limited. We therefore examined the prevalence and associated factors of impaired renal function and albuminuria among adult patients admitted to the internal medicine wards of a hospital in Northeast Ethiopia.
METHODS
A cross-sectional study was conducted from January 1 to April 30, 2020 at the inpatient settings of Dessie referral hospital. Data on demographics and medical history were obtained, and serum creatinine and albuminuria were analyzed. Estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as impaired eGFR (<60 ml/min/1.73m2) and/or albuminuria. Univariate and multivariable analysis were conducted to determine factors associated with impaired eGFR and albuminuria.
RESULTS
A total of 369 patients were included in this study. The prevalence of impaired eGFR was 19.0% (95%CI: 15.2%-23.2%) and albuminuria was 30.9% (95%CI: 26.3%-35.7%). Overall, 33.9% (95%CI: 29.2%-38.9%) of the patients had some degree of CKD, but only 21.6% (95%CI: 15.1%-29.4%) were aware of their renal disease. In multivariable analysis, older age, a family history of kidney disease, diabetes, hypertension and HIV were independently associated with both impaired eGFR and albuminuria while male gender was independently associated with only albuminuria.
CONCLUSIONS
CKD is common in adult patients admitted to the internal medicine wards, but only few patients are aware of their condition. These findings highlight the need for feasible approaches to timely identify kidney disease and raise awareness on the importance of detection and early intervention in the inpatient settings.
背景
慢性肾脏病（CKD）在住院患者中越来越常见，与住院期间发病率和死亡率增加有关。然而，关于非洲住院患者人群中 CKD 的患病率数据有限。因此，我们研究了埃塞俄比亚东北部一家医院内科病房成年患者中肾功能不全和白蛋白尿的患病率及相关因素。
方法
这是一项 2020 年 1 月 1 日至 4 月 30 日在德西转诊医院住院病房进行的横断面研究。收集人口统计学和病史数据，并分析血清肌酐和白蛋白尿。使用肾脏病饮食改良公式（MDRD）计算估计肾小球滤过率（eGFR）。CKD 的定义为 eGFR 受损（<60 ml/min/1.73m2）和/或白蛋白尿。进行单变量和多变量分析，以确定与 eGFR 受损和白蛋白尿相关的因素。
结果
本研究共纳入 369 例患者。eGFR 受损的患病率为 19.0%（95%CI：15.2%-23.2%），白蛋白尿的患病率为 30.9%（95%CI：26.3%-35.7%）。总的来说，33.9%（95%CI：29.2%-38.9%）的患者患有某种程度的 CKD，但只有 21.6%（95%CI：15.1%-29.4%）知晓自己的肾脏疾病。多变量分析显示，年龄较大、有肾脏疾病家族史、糖尿病、高血压和 HIV 与 eGFR 受损和白蛋白尿均独立相关，而男性仅与白蛋白尿独立相关。
结论
CKD 在住院内科病房的成年患者中很常见，但只有少数患者知晓自己的病情。这些发现强调了需要采取可行的方法及时发现肾脏疾病，并提高对住院患者中发现和早期干预重要性的认识。
Zotero 插件