Kursawe Larsen C, Kjaersgaard Andersen R, Kirby J S, Tan J, Saunte D M L, Jemec G B E
Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
Department of Dermatology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
J Eur Acad Dermatol Venereol. 2021 Jul;35(7):1577-1581. doi: 10.1111/jdv.17148. Epub 2021 Mar 3.
Hidradenitis suppurativa (HS) is a painful chronic, recurrent inflammatory skin disease with great impact on health-related quality of life (HRQOL). Recently, Hidradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC) established HRQOL as a core domain set for HS clinical trials and developed the Hidradenitis Suppurativa Quality of Life (HiSQOL) as a validated outcome measurement instrument.
To provide further convergent validity of HiSQOL by comparing it to Dermatology Life Quality Index (DLQI) and Pictorial Representation of Illness and Self Measure-Revised 2 (PRISM-R2).
In this cross-sectional study, 103 participants completed HiSQOL, PRISM-R2 and DLQI. PRISM-R2 is an instrument designed to measure suffering and reports the two measures, Illness Perception Measure (IPM) and Self-Illness Separation (SIS). Correlation analyses were performed including a sub-analysis for a subgroup of patients with high scores in the HS-specific domains of HiSQOL.
A very strong correlation was found between HiSQOL and DLQI (ρ = 0.93, P < 2.2 × 10 , (95% CI: 0.89;0.95)), and moderately strong correlations were found between HiSQOL and SIS (ρ = -0.73, P < 2.2 × 10 , (95% CI: -0.81; -0.62)) and DLQI and SIS (ρ = -0.70, P < 2.2 × 10 , (95% CI: -0.79; -0.59)). IPM was positively associated with HiSQOL and DLQI and negatively with SIS.
HiSQOL is a valid measure of quality of life for HS patients, and we suggest that HiSQOL can be used as a measure of suffering as well.
化脓性汗腺炎（HS）是一种疼痛的慢性复发性炎症性皮肤病，对健康相关生活质量（HRQOL）有很大影响。最近，化脓性汗腺炎核心结局集国际协作组（HISTORIC）将HRQOL确立为HS临床试验的一个核心领域集，并开发了化脓性汗腺炎生活质量量表（HiSQOL）作为一种经过验证的结局测量工具。
通过将HiSQOL与皮肤病生活质量指数（DLQI）和疾病与自我测量修订版2（PRISM-R2）进行比较，为HiSQOL提供进一步的收敛效度。
在这项横断面研究中，103名参与者完成了HiSQOL、PRISM-R2和DLQI。PRISM-R2是一种旨在测量痛苦程度的工具，并报告疾病认知测量（IPM）和自我与疾病分离（SIS）这两项指标。进行了相关性分析，包括对HiSQOL特定领域得分较高的患者亚组的亚分析。
发现HiSQOL与DLQI之间存在非常强的相关性（ρ = 0.93，P < 2.2×10⁻¹⁶，（95%CI：0.89；0.95）），HiSQOL与SIS之间存在中度强相关性（ρ = -0.73，P < 2.2×10⁻¹⁶，（95%CI：-0.81；-0.62）），DLQI与SIS之间存在中度强相关性（ρ = -0.70，P < 2.2×10⁻¹⁶，（95%CI：-0.79；-0.59））。IPM与HiSQOL和DLQI呈正相关，与SIS呈负相关。
HiSQOL是HS患者生活质量的有效测量工具，我们建议HiSQOL也可作为痛苦程度的测量工具。
