Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.
Appl Neuropsychol Adult. 2022 Nov-Dec;29(6):1387-1393. doi: 10.1080/23279095.2021.1880409. Epub 2021 Feb 4.
The Independent Living Scales (ILS) is an objective measure of day-to-day functioning, which can be used to aid in diagnosing dementia in older adults with cognitive impairments. However, no studies have examined this measure longitudinally in individuals with mild cognitive impairment (MCI), a prodromal phase of dementia. Three subscales of the ILS (Managing Money, Managing Home and Transportation, Health and Safety) were administered to a sample of 94 individuals with amnestic MCI twice across 15 months. A measure of global cognition (Total Scale score on the Repeatable Battery for the Assessment of Neuropsychological Status [RBANS]) was also administered twice. In this MCI sample, two of the three subscales of the ILS showed a significant decline over time, where the third ILS subscale and the Total Scale score of the RBANS did not change. Regression-based change models showed that baseline ILS scores were most strongly predictive of follow-up ILS scores compared to RBANS scores at baseline and follow-up and demographic variables (age, education, and sex). These results provide additional information on the longitudinal change on the ILS in a sizeable cohort of older individuals with amnestic MCI, which may make this scale more useful in identifying progression to dementia.
独立生活量表（ILS）是一种客观的日常生活功能衡量标准，可用于帮助诊断认知障碍老年人的痴呆症。然而，尚无研究在轻度认知障碍（MCI）个体中对该指标进行纵向研究，MCI 是痴呆的前驱阶段。对 94 名有遗忘型 MCI 的个体进行了 ILS 的三个分量表（管理金钱、管理家庭和交通、健康和安全）的测试，在 15 个月内进行了两次。还对认知功能的总体衡量标准（重复神经心理状态评估电池的总量表得分[RBANS]）进行了两次测试。在这个 MCI 样本中，ILS 的三个分量表中的两个随时间显示出明显的下降，而第三个 ILS 分量表和 RBANS 的总量表得分没有变化。基于回归的变化模型表明，与基线和随访时的 RBANS 评分以及人口统计学变量（年龄、教育和性别）相比，基线 ILS 评分对随访 ILS 评分的预测能力最强。这些结果提供了关于在遗忘型 MCI 的大量老年个体中 ILS 的纵向变化的更多信息，这可能使该量表在识别向痴呆的进展方面更有用。
