Center for Alzheimer's Care, Imaging and Research, Department of Neurology, University of Utah , Salt Lake City, UT, USA.
J Clin Exp Neuropsychol. 2020 Sep;42(7):725-734. doi: 10.1080/13803395.2020.1798884. Epub 2020 Aug 3.
The Independent Living Scales (ILS) is an objective measure of day-to-day functioning, which can be used to aid in diagnosing dementia in older adults with cognitive impairments. However, no studies have examined this measure in individuals with Mild Cognitive Impairment (MCI), a prodromal phase of dementia.
Therefore, we sought to examine three subscales of the ILS (Managing Money, Managing Home and Transportation, Health and Safety) in a sample of 132 individuals with amnestic MCI, focusing on the relationship of the ILS with demographic variables (age, education, sex) and cognitive abilities (assessed with the Repeatable Battery for the Assessment of Neuropsychological Status [RBANS]).
This MCI sample showed intact daily functioning on the three ILS subscales. In a series of three, separate hierarchical linear regression models, the Managing Money, Managing Home and Transportation, and Health and Safety subscales were all significantly related to demographic variables, and the RBANS Total Scale score significantly added to all models. These models would also allow one to predict an ILS score based on demographic and cognitive data, which could be compared to an observed ILS score to see if it meets expectations.
Overall, these results indicate that daily functioning, as measured with the ILS, is related to cognitive abilities in amnestic MCI, and that demographic variables also influenced ILS scores in this cohort. Although the ILS may be appropriate for identifying functional abilities in MCI, the consideration of these moderating variables seems necessary.
独立生活量表（ILS）是一种衡量日常生活功能的客观指标，可用于帮助诊断认知障碍老年人的痴呆症。然而，尚无研究在轻度认知障碍（MCI）患者中检查这种测量方法，MCI 是痴呆的前期阶段。
因此，我们试图在 132 名有遗忘型 MCI 的个体中检查 ILS 的三个分量表（管理金钱、管理家庭和交通、健康和安全），重点关注 ILS 与人口统计学变量（年龄、教育、性别）和认知能力（使用重复性成套神经心理状态评估量表 [RBANS] 评估）的关系。
这个 MCI 样本在三个 ILS 分量表上的日常功能都完好无损。在三个独立的分层线性回归模型中，管理金钱、管理家庭和交通以及健康和安全分量表均与人口统计学变量显著相关，RBANS 总评分显著增加了所有模型。这些模型还可以根据人口统计学和认知数据预测 ILS 得分，并将其与观察到的 ILS 得分进行比较，以查看是否符合预期。
总体而言，这些结果表明，ILS 测量的日常生活功能与遗忘型 MCI 的认知能力相关，并且人口统计学变量也会影响该队列中的 ILS 评分。尽管 ILS 可能适合识别 MCI 中的功能能力，但考虑这些调节变量似乎是必要的。
