将 CHRNA5 SNP 与药物滥用易感性联系起来：从电路到细胞机制。
Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms.
机构信息
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
出版信息
Neuropharmacology. 2021 Mar 15;186:108480. doi: 10.1016/j.neuropharm.2021.108480. Epub 2021 Feb 1.
Abstract
Genetics are known to be a significant risk factor for drug abuse. In human populations, the single nucleotide polymorphism (SNP) D398N in the gene CHRNA5 has been associated with addiction to nicotine, opioids, cocaine, and alcohol. In this paper, we review findings from studies in humans, rodent models, and cell lines and provide evidence that collectively suggests that the Chrna5 SNP broadly influences the response to drugs of abuse in a manner that is not substance-specific. This finding has important implications for our understanding of the role of the cholinergic system in reward and addiction vulnerability. This article is part of the special issue on 'Vulnerabilities to Substance Abuse.'
摘要
遗传学被认为是药物滥用的一个重要风险因素。在人类群体中，基因 CHRNA5 中的单核苷酸多态性 (SNP) D398N 与尼古丁、阿片类药物、可卡因和酒精成瘾有关。在本文中，我们综述了来自人类、啮齿动物模型和细胞系的研究结果，并提供了证据表明，Chrna5 SNP 广泛地以非物质特异性的方式影响对滥用药物的反应。这一发现对我们理解胆碱能系统在奖赏和成瘾易感性中的作用具有重要意义。本文是“物质滥用易感性”特刊的一部分。
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