UMI 233 IRD-UM Inserm U1175 TransVIHMI, Infections Fongique et Parasitaire Laboratoire de Parasitologie et de Mycologie Médicale, UFR Pharmacie, Montpellier cedex 5, France.
Laboratoire de Parasitologie et de Mycologie - CeDReS (Centre de Diagnostic et de Recherche sur le SIDA et les Autres Maladies Infectieuses), UFR Pharmacie, CHU de Treichville, Université Félix Houphouët Boigny, Abidjan, Ivory Coast.
J Mycol Med. 2021 Jun;31(2):101113. doi: 10.1016/j.mycmed.2021.101113. Epub 2021 Jan 16.
Cryptococcus gattii species complex is endemic to tropical and subtropical regions and is described as a causative agent of cryptococcosis in immunocompetent individuals.
We describe the first case of cryptococcosis in a HIV-negative patient from Ivory Coast infected by Cryptococcus gattii sensu stricto VGI. Isolates were recovered from cerebrospinal fluid (CSF) prior to systemic antifungal treatment up to 42 days after detection of the presence of yeasts in the CSF. Eighteen isolates were recovered, genetic diversity and antifungal susceptibility analyses were performed. All the isolates belonged to the Cryptococcus gattii sensu stricto (B;VGI) and were identified as a new sequence type (ST) 553 by Multilocus Sequence Typing (MLST) analyses. Susceptibility testing showed that all the strains had a wild-type phenotype for fluconazole, amphotericin B and flucytosine. Treatment with fluconazole (1200mg/day) was initiated with success.
This is the first case report of the presence of C. gattii sensu stricto VGI in a HIV-negative ivorian patient and the second report of the presence of species from the C. gattii complex species in this country.
新生隐球菌物种复合体流行于热带和亚热带地区，被描述为免疫功能正常个体中 cryptococcosis 的致病因子。
我们描述了来自科特迪瓦的首例 HIV 阴性患者的 cryptococcosis 病例，该患者感染了新生隐球菌严格意义上的 VGI。在系统性抗真菌治疗之前，从脑脊液 (CSF) 中分离出了真菌，直到 CSF 中检测到真菌存在后 42 天。共分离出 18 株，进行了遗传多样性和抗真菌药敏分析。所有分离株均属于新生隐球菌严格意义上的种 (B; VGI)，通过多位点序列分型 (MLST) 分析鉴定为新的序列型 (ST) 553。药敏试验显示，所有菌株对氟康唑、两性霉素 B 和氟胞嘧啶均表现出野生型表型。成功开始了氟康唑 (1200mg/天) 的治疗。
这是首例报告在科特迪瓦 HIV 阴性患者中存在新生隐球菌严格意义上的 VGI，也是该国报告的第二种存在新生隐球菌复合体种的病例。
