哥伦比亚分离的临床隐球菌属的药敏性因分子型而异。
Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types.
机构信息
Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, 111221, Colombia.
Group of Microbiology, Instituto Nacional de Salud, Bogota, 111221, Colombia.
出版信息
Med Mycol. 2021 Nov 3;59(11):1122-1125. doi: 10.1093/mmy/myab041.
UNLABELLED
Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole, and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis.
LAY SUMMARY
Cryptococcosis gattii affects immunocompetent people. For a correct treatment, antifungal susceptibility testing is essential. This study shows differences in the susceptibility to commonly used antimycotics among genotypes of Colombian clinical C. gattii isolates, some of which are non-wild-type.
未标注
隐球菌病由新型隐球菌在哥伦比亚流行，主要影响免疫功能正常的宿主。由于其他地方报道过，隐球菌分离株的分子类型不同，抗真菌药物敏感性也不同，因此本研究旨在使用 Sensititre 板确定 42 株来自哥伦比亚的临床分离株（VGI、VGII 和 VGIII）是否对常用抗真菌药物的敏感性存在差异。在这些分子类型中，发现了 6 株对氟康唑、伏立康唑和 5-氟胞嘧啶非野生型的分离株。此外，与其他分子类型相比，VGI 和 VGII 对 5-氟胞嘧啶和唑类药物的敏感性分别较低。这些发现支持进行药敏试验的适用性，这可以更好地指导隐球菌病的治疗。
摘要
新型隐球菌病影响免疫功能正常的人群。为了正确治疗，抗真菌药物敏感性测试是必不可少的。本研究显示了来自哥伦比亚新型隐球菌临床分离株的基因型对常用抗真菌药物敏感性存在差异，其中一些为非野生型。
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