Department of Ophthalmology, Shanghai Eye Disease Prevention & Treatment Center, Shanghai, China.
Shanghai Pharmacies Medical & Biotechnology Co., Ltd, Shanghai, China.
Ophthalmic Res. 2022;65(4):466-473. doi: 10.1159/000515013. Epub 2021 Feb 4.
The aim of this study was to evaluate the short-term efficacy and safety of ultrasound cycloplasty (UCP) procedure in Chinese glaucoma patients.
As a single-center, prospective, noncomparative study, 23 eyes of 23 patients suffering from glaucoma with uncontrolled intraocular pressure (IOP) ≥21 mm Hg underwent a multidose UCP treatment with the activations of 6, 8, or10 sectors. Types of glaucoma include primary open-angle glaucoma (7/23), primary angle closure glaucoma (PACG) (9/23), and secondary glaucoma (SG) (7/23). A complete ophthalmic examination including intraocular pressure (IOP) measurements was performed before UCP procedure and at 1 day, 1 month, 3 months, and 6 months after the procedure. An IOP reduction of ≥20% and IOP >5 mm Hg without increasing hypotensive medication at the follow-up visit was defined as therapeutic success. The postoperative complications were also recorded and compared to baseline for safety evaluation.
The mean baseline IOP of 23 treated eyes was 37.2 ± 12.1 mm Hg. The IOP reduction after UCP procedure was 23, 49, 33, and 34% at 1 day, 1 month, 3 months, and 6 months, respectively. Thus, the corresponding overall therapeutic success rates reached 61% (14/23), 83% (19/23), 65% (15/23), and 61% (14/23), respectively. Baseline IOPs of 8- and 10-sector groups (37.0 ± 9.9 mm Hg and 50.1 ± 12.2 mm Hg) were significantly higher than that of 6 sector groups (30.1 ± 8.2 mm Hg). Therapeutic success rates of 6-, 8-, and 10-sector groups reached 44% (4/9), 56% (5/9), and 100% (5/5), respectively. There were the highest percentage of IOP reduction (50 and 41%) and therapeutic success rate (6/7; 86% and 7/9; 78%) in the SG group and PACG group, respectively. In addition, preoperative ocular pain symptoms of 4 patients were all disappeared within 1 week after UCP. No serious intraoperative or postoperative complications occurred.
UCP procedure is an effective and well-tolerated treatment to reduce IOP in Chinese glaucoma patients, which offered a novel alternative for glaucoma treatment.
本研究旨在评估超声小梁成形术（UCP）在中国青光眼患者中的短期疗效和安全性。
这是一项单中心、前瞻性、非对照研究，23 例（23 只眼）眼压（IOP）控制不佳（≥21mmHg）的青光眼患者接受了 UCP 多剂量治疗，激活了 6、8 或 10 个扇区。青光眼类型包括原发性开角型青光眼（7/23）、原发性闭角型青光眼（PACG）（9/23）和继发性青光眼（SG）（7/23）。在 UCP 术前和术后 1 天、1 个月、3 个月和 6 个月进行全面眼科检查，包括 IOP 测量。随访时眼压降低≥20%且降压药物无增加定义为治疗成功。还记录了术后并发症并与基线进行了比较以进行安全性评估。
23 只治疗眼的平均基线 IOP 为 37.2±12.1mmHg。UCP 术后 1 天、1 个月、3 个月和 6 个月的 IOP 降低分别为 23%、49%、33%和 34%。因此，相应的总体治疗成功率分别达到 61%（14/23）、83%（19/23）、65%（15/23）和 61%（14/23）。8 扇区和 10 扇区组（37.0±9.9mmHg 和 50.1±12.2mmHg）的基线 IOP 明显高于 6 扇区组（30.1±8.2mmHg）。6 扇区、8 扇区和 10 扇区组的治疗成功率分别为 44%（4/9）、56%（5/9）和 100%（5/5）。SG 组和 PACG 组的 IOP 降低百分比最高（分别为 50%和 41%）和治疗成功率最高（分别为 6/7；86%和 7/9；78%）。此外，4 例患者术前眼部疼痛症状均在 UCP 后 1 周内消失。无严重术中或术后并发症发生。
UCP 是一种有效且耐受良好的降低中国青光眼患者 IOP 的治疗方法，为青光眼治疗提供了一种新的选择。
