Institute for Advanced and Applied Chemical Synthesis, Jinan University, Zhuhai 519070, China.
Molecules. 2021 Feb 2;26(3):765. doi: 10.3390/molecules26030765.
The title alkaloids, often referred to collectively as crinines, are a prominent group of structurally distinct natural products with additional members being reported on a regular basis. As such, and because of their often notable biological properties, they have attracted attention as synthetic targets since the mid-1950s. Such efforts continue unabated and more recent studies on these alkaloids have focused on using them as vehicles for showcasing the utility of new synthetic methods. This review provides a comprehensive survey of the nearly seventy-year history of these synthetic endeavors.
标题生物碱，通常统称为藜宁生物碱，是一组结构独特的天然产物，其成员经常被定期报道。因此，由于它们通常具有显著的生物特性，自 20 世纪 50 年代中期以来，它们一直作为合成目标引起人们的关注。这些努力仍在继续，最近对这些生物碱的研究集中在利用它们作为展示新合成方法效用的载体。本综述全面概述了这些合成工作近 70 年的历史。
