Tang Saiyi, Shu Xinhua
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Jan 5;35(1):80-84. doi: 10.13201/j.issn.2096-7993.2021.01.021.
Respiratory allergic disease mainly include asthma and allergic rhinitis.According to their extremely similarpathogenesis and inflammatory pathological changes,asthma and allergic rhinitis,are regarded as the concept of "one airway, one disease". In recent years, The research on the target of allergens in the pathogenesis mechanism is more in-depth, and the CCR3 gene is a major research target. The study found that the CCR3 gene is an important target gene for the development of respiratory allergic diseases such as allergic rhinitis and asthma. The related inflammatory cells are the main cells responding for the downstream cascade triggered by CCR3 activation, which directly or indirectly cause allergic inflammation through itself or its secretions.Therefore, researches on the roles of CCR3 gene and its related inflammatory cells become hot topics in the clinical treatment of respiratory allergic diseases. This paper reviews the current research progress of respiratory allergic diseases on the basis of intensive literature.
呼吸道过敏性疾病主要包括哮喘和过敏性鼻炎。由于哮喘和过敏性鼻炎的发病机制及炎症病理变化极为相似，它们被视为“同一气道，同一种疾病”的概念。近年来，对发病机制中过敏原靶点的研究更加深入，CCR3基因是主要研究靶点。研究发现，CCR3基因是过敏性鼻炎和哮喘等呼吸道过敏性疾病发展的重要靶基因。相关炎症细胞是CCR3激活触发的下游级联反应的主要应答细胞，它们通过自身或其分泌物直接或间接引起过敏性炎症。因此，CCR3基因及其相关炎症细胞的作用研究成为呼吸道过敏性疾病临床治疗的热点话题。本文在大量文献的基础上综述了呼吸道过敏性疾病的当前研究进展。
