Yale School of Medicine, Yale New Haven Health, LCI-106, 20 York Street, New Haven, CT 06519, USA.
Weill Cornell Medical College, New York Presbyterian-Weill Cornell Medical Center, Starr Pavilion, 520 East 70th Street, 4th Floor, New York City, NY 10021, USA.
Clin Chest Med. 2021 Mar;42(1):91-99. doi: 10.1016/j.ccm.2020.10.006. Epub 2021 Jan 9.
Pregnancy in pulmonary hypertension (PH) is associated with a high maternal morbidity and mortality. The normal physiologic pulmonary and systemic hemodynamic alterations that occur during pregnancy are poorly tolerated during pregnancy, birth, and the immediate postpartum period. This article (a) highlights the normal anatomic and physiologic changes that accompany pregnancy and the potential deleterious consequences on the cardiopulmonary circulation in pregnant PH patients and (b) provides an in-depth approach in the management of the pregnant PH patient.
妊娠合并肺动脉高压(PH)与母体发病率和死亡率高有关。妊娠期间发生的正常的肺和全身血流动力学改变在妊娠、分娩和产后即刻期间很难耐受。本文(a)重点介绍了妊娠期间伴随的正常解剖和生理变化,以及对妊娠 PH 患者心肺循环的潜在有害后果;(b)提供了妊娠 PH 患者管理的深入方法。