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高血糖高渗状态:有复杂医疗需求的青少年首诊 1 型糖尿病。

Hyperglycaemic hyperosmolar state: first presentation of type 1 diabetes mellitus in an adolescent with complex medical needs.

机构信息

College of Medicine and Veterinary Medicine, University of Edinburgh Division of Medical and Radiological Sciences, Edinburgh, Edinburgh, UK

Paediatrics, Northampton General Hospital NHS Trust, Northampton, Northamptonshire, UK.

出版信息

BMJ Case Rep. 2021 Feb 4;14(2):e237793. doi: 10.1136/bcr-2020-237793.

Abstract

This is a case of hyperglycaemic hyperosmolar state (HHS) as first presentation of type 1 diabetes mellitus in a 14-year-old girl with background complex medical needs. She presented with marked hyperglycaemia (56 mmol/L) without significant ketonaemia (2.6 mmol/L) and serum hyperosmolality (426 mOsm/kg). Managing her profound hypernatraemic (>180 mmol/L) dehydration was challenging but resulted in good outcome. Paediatric patients with HHS will likely be treated with the diabetes ketoacidosis (DKA) protocol because of perceived rarity of HHS leading to inadequate rehydration and risk of vascular collapse. Hence, emphasis on the differences in the management protocols of DKA and HHS is paramount. Prompt recognition and adequate management are crucial to avert complications. The undesirable rate of decline of hypernatraemia due to the use of hypotonic fluid was captured in this case. We describe the pivotal role of liberal fluid therapy with non-hypotonic fluids.

摘要

这是一例以高血糖高渗状态(HHS)为首发表现的 1 型糖尿病,患者为 14 岁女孩,有复杂的基础医疗需求。她表现为明显的高血糖(56mmol/L),但无显著酮血症(2.6mmol/L)和血清高渗状态(426mOsm/kg)。管理她严重的高钠血症(>180mmol/L)脱水是具有挑战性的,但结果良好。由于 HHS 的罕见性,儿科 HHS 患者可能会按照糖尿病酮症酸中毒(DKA)方案进行治疗,导致补液不足和血管塌陷风险。因此,强调 DKA 和 HHS 管理方案的差异至关重要。及时识别和充分管理对于避免并发症至关重要。在这种情况下,由于使用低渗液,高钠血症的下降速度不理想。我们描述了使用非低渗液进行自由液体治疗的关键作用。

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