Udén P, Blomquist P, Jiborn H, Zederfeldt B
Department of Surgery, Lund University, Malmö, Sweden.
Acta Chir Scand. 1988 Feb;154(2):127-32.
The impact of colostomy closure on the healing of a left colonic anastomosis performed 4 weeks earlier was studied in rats. Colostomy closure could be safely accomplished but in 3 of 25 rats was followed by faecal obstruction due to narrowing of the primary left colonic anastomosis. After colostomy closure the gain in anastomotic strength was slow and did not exceed the outset value until after 3 weeks. After colostomy closure, accumulation of collagen in the anastomotic region increased earlier than anastomotic strength, indicating delay in collagen maturation.
在大鼠中研究了结肠造口关闭对4周前进行的左结肠吻合口愈合的影响。结肠造口关闭可以安全完成，但25只大鼠中有3只在结肠造口关闭后因原左结肠吻合口狭窄出现粪便梗阻。结肠造口关闭后，吻合口强度增加缓慢，直到3周后才超过初始值。结肠造口关闭后，吻合口区胶原蛋白的积累比吻合口强度增加得更早，表明胶原蛋白成熟延迟。
