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鞘内注射巴氯芬泵植入术前后脑瘫患儿的肌肉骨骼疼痛结局:一项前瞻性队列研究

Musculoskeletal Pain Outcomes Pre- and Post Intrathecal Baclofen Pump Implant in Children With Cerebral Palsy: A Prospective Cohort Study.

作者信息

Barney Chantel C, Merbler Alyssa M, Stansbury Jean, Krach Linda E, Partington Michael, Graupman Patrick, Kim Peter D, Song Debbie, Symons Frank J

机构信息

Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota.

Gillette Children's Specialty Healthcare, St Paul, Minnesota.

出版信息

Arch Rehabil Res Clin Transl. 2020 Mar 9;2(2):100049. doi: 10.1016/j.arrct.2020.100049. eCollection 2020 Jun.

Abstract

OBJECTIVE

To characterize musculoskeletal pain intensity, duration, frequency, and interference with activities of daily living in children with cerebral palsy (CP) before and after intrathecal baclofen pump placement.

DESIGN

Prospective cohort study.

SETTING

Children's tertiary hospital.

PARTICIPANTS

Participants were children with CP (N=32; 53% male; mean age, 9.9y; age range, 4-17y). The majority of participants had a CP diagnosis of quadriplegia (76%) and relied on wheeled mobility (91%).

INTERVENTIONS

Assessments were completed pre- and post intrathecal baclofen pump implant.

MAIN OUTCOME MEASURES

Because of considerable patient heterogeneity, both pain measures (Brief Pain Inventory, Dalhousie Pain Interview) were completed by proxy (parent) report at the time of the procedure and approximately 6 months after intrathecal baclofen (ITB) pump placement.

RESULTS

Prior to implant, 31% of participants were living with constant pain, which reduced to 6% post ITB implant (<.001). Based on Wilcoxon signed rank tests, pain duration significantly decreased post ITB pump implant (<.01).

CONCLUSIONS

This prospective analysis supports the anecdotal and retrospective evidence that musculoskeletal pain decreases in CP following ITB pump implant. The greatest effect appears to be on the duration of pain experience. Pain did not decrease for all individuals, and it would be worth further investigation to better understand the relation between patient characteristics and pain outcomes.

摘要

目的

描述鞘内注射巴氯芬泵植入前后脑瘫(CP)患儿的肌肉骨骼疼痛强度、持续时间、频率以及对日常生活活动的干扰。

设计

前瞻性队列研究。

地点

儿童三级医院。

参与者

参与者为CP患儿(N = 32;53%为男性;平均年龄9.9岁;年龄范围4 - 17岁)。大多数参与者被诊断为四肢瘫痪型CP(76%),并依赖轮椅出行(91%)。

干预措施

在鞘内注射巴氯芬泵植入前后完成评估。

主要观察指标

由于患者存在显著异质性,两种疼痛测量方法(简明疼痛量表、达尔豪西疼痛访谈)均通过代理(家长)报告在手术时以及鞘内注射巴氯芬(ITB)泵植入后约6个月完成。

结果

植入前,31%的参与者持续疼痛,ITB植入后这一比例降至6%(<.001)。基于Wilcoxon符号秩检验,ITB泵植入后疼痛持续时间显著缩短(<.01)。

结论

这项前瞻性分析支持了轶事证据和回顾性证据,即ITB泵植入后CP患儿的肌肉骨骼疼痛减轻。最大的影响似乎在于疼痛经历的持续时间。并非所有个体的疼痛都有所减轻,进一步研究以更好地理解患者特征与疼痛结果之间的关系将是值得的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab30/7853392/7d6cb5e143d7/gr1.jpg

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