Wen Xiaowei, Liu Xiaojuan, Yang Zhiqi, Xie Menglan, Liu Yuxi, Long Lipeng, Chen Zhengwang
Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, 341000, China.
Org Biomol Chem. 2021 Mar 4;19(8):1738-1743. doi: 10.1039/d1ob00073j.
An efficient nano-Cu2O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as a solvent, affording versatile N-substituted phthalimide derivatives in moderate to excellent yields. This novel strategy features carbon monoxide gas-free, environmentally benign, one-pot multistep transformation, commercially available reagents, a cheap catalyst without any additives, wide functional group tolerance, and operational convenience.
