Yan Weidan, Luo Hong, Wu Qiling, Liu Liansheng, Li Jing, Wei Junfa
School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.
J Org Chem. 2022 Aug 19;87(16):10858-10868. doi: 10.1021/acs.joc.2c01164. Epub 2022 Aug 10.
A Cp*Rh-catalyzed efficient synthesis of isoquinolin-3-ol derivatives bearing a pyridinyl ring using imidate as a directing group under C-H activation strategy with pyridotriazoles as carbene reagents is reported. In this reaction, cascade C-H activation, regioselective cyclization, and elimination occur in one pot. The present methodology featured a good range of functional group tolerance and furnished the target products in moderate-to-excellent yields.
报道了一种Cp*Rh催化的高效合成带有吡啶基环的异喹啉-3-醇衍生物的方法，该方法以亚胺酯作为导向基团，在C-H活化策略下，使用吡啶三唑作为卡宾试剂。在该反应中，级联C-H活化、区域选择性环化和消除反应在一锅法中进行。该方法具有良好的官能团耐受性，能以中等到优异的产率得到目标产物。
