Department of Psychiatry, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Schizophr Bull. 2021 Apr 29;47(3):583-585. doi: 10.1093/schbul/sbab008.
There has been a major drive in research trying to understand the onset of psychosis. Clinical-high risk (CHR) studies focus on opportunistic help-seeking samples with non-psychotic disorders and a degree of psychosis admixture of variable outcome, but it is unlikely that these represent the population incidence of psychotic disorders. Longitudinal cohort studies of representative samples in the general population have focused on development and outcome of attenuated psychotic symptoms, but typically have low power to detect transition to clinical psychotic disorder. In this issue of Schizophrenia Bulletin, Cupo and colleagues resurrect a time-honored method to examine psychosis onset: the epidemiological follow-back study, modernizing it to fit the research framework of the early intervention era. The authors set out to investigate the hypothesis that psychotic disorder represents the poorest outcome fraction of initially non-psychotic, common mental disorders and present compelling findings, unifying previous opportunistic CHR and representative cohort-based work.
研究人员一直在大力研究精神分裂症的发病机制。临床高风险 (CHR) 研究主要针对有非精神病性障碍和一定程度精神分裂症混合表现的机会性寻求帮助的样本，但这些样本不太可能代表精神病性障碍的人群发病率。代表性的一般人群纵向队列研究侧重于缓解性精神病症状的发展和结果，但通常没有足够的能力来检测向临床精神病性障碍的转变。在本期《精神分裂症通报》中，Cupo 及其同事重新采用了一种久经考验的方法来研究精神分裂症的发病：流行病学回溯研究，并将其现代化，以适应早期干预时代的研究框架。作者旨在调查精神分裂症代表最初非精神病性常见精神障碍中预后最差的部分这一假说，并提出了令人信服的发现，统一了以前的机会性 CHR 和基于代表性队列的研究。
