Vandenberg B F, Feinstein S B, Kieso R A, Hunt M, Kerber R E
Department of Medicine, University of Iowa Hospital, Iowa City 52242.
Am Heart J. 1988 Apr;115(4):733-9. doi: 10.1016/0002-8703(88)90872-1.
Contrast agents were injected via the intracoronary route in eight dogs during two-dimensional echocardiographic imaging to determine the influence of microbubble size and concentration, injection rate, and coronary vasodilation on risk area and peak gray level measurement. At an injection rate at 13 cc/sec, the average background-subtracted peak gray level intensity of hand-agitated diatrizoate meglumine/diatrizoate sodium was significantly (p less than 0.01) higher than that of hand-agitated diatrizoate meglumine/diatrizoate sodium + 0.9% saline, sonicated diatrizoate meglumine/diatrizoate sodium, and sonicated 70% sorbitol. These differences were abolished by the use of 38 cc/sec injection rates and intracoronary injection of adenosine. Perfusion area determinations as assessed by planimetry were unaffected by the contrast agent used, the injection rate, or by intracoronary administration of adenosine. We conclude that risk area measurement by the ultrasound contrast technique is not affected by varying contrast agents, injection rates, or vasodilation. However, peak gray level intensity is variable among contrast agents and may result in variability of time-activity curve analysis.
在二维超声心动图成像期间，通过冠状动脉内途径向8只狗注射造影剂，以确定微泡大小、浓度、注射速率和冠状动脉扩张对危险区域和峰值灰度测量的影响。在13毫升/秒的注射速率下，手工搅拌的泛影葡胺/泛影酸钠的平均背景扣除峰值灰度强度显著（p<0.01）高于手工搅拌的泛影葡胺/泛影酸钠+0.9%盐水、超声处理的泛影葡胺/泛影酸钠和超声处理的70%山梨醇。使用38毫升/秒的注射速率和冠状动脉内注射腺苷可消除这些差异。通过面积测量法评估的灌注面积测定不受所用造影剂、注射速率或冠状动脉内给予腺苷的影响。我们得出结论，超声造影技术测量危险区域不受造影剂、注射速率或血管扩张变化的影响。然而，不同造影剂的峰值灰度强度是可变的，这可能导致时间-活性曲线分析的变异性。
