Moore C A, Smucker M L, Kaul S
J Am Coll Cardiol. 1986 Nov;8(5):1066-72. doi: 10.1016/s0735-1097(86)80383-7.
Myocardial contrast echocardiography is a new diagnostic cardiovascular imaging technique capable of defining perfusion zones of coronary vessels in vivo; ultimately, it may be used to measure absolute regional myocardial blood flow. However, before it can be used in humans, its safety must be clearly established. Accordingly, the electrocardiographic and hemodynamic effects of intracoronary injections of 2 cc of sonicated Renografin-76 were compared with 5 to 10 cc of non-sonicated Renografin-76 in 10 subjects with normal coronary arteries. Two cubic centimeters of sonicated Renografin provides optimal myocardial opacification during echocardiography, while 5 to 10 cc of Renografin is required for an adequate coronary arteriogram. During coronary arteriography, heart rate decreased while PR and QT intervals and QRS duration increased as compared with baseline and myocardial contrast echocardiography (p less than 0.01). Similarly, the decrease in aortic pressure and first derivative of left ventricular pressure (dP/dt) was significantly (p less than 0.01) greater during routine coronary arteriography than during myocardial contrast echocardiography. Changes in left ventricular end-diastolic or pulmonary capillary wedge pressure were similar during myocardial contrast echocardiography and coronary angiography. There were no significant differences in the duration of electrocardiographic and hemodynamic changes between myocardial contrast echocardiography and coronary arteriography. It is concluded that intracoronary injection of 2 cc of sonicated Renografin-76 provides optimal myocardial opacification. It is safe in humans, producing transient electrocardiographic and hemodynamic alterations that are less pronounced than those seen during routine coronary angiography.
心肌对比超声心动图是一种新型的诊断性心血管成像技术，能够在体内确定冠状动脉的灌注区域；最终，它可能会被用于测量绝对区域心肌血流量。然而，在其应用于人体之前，必须明确其安全性。因此，在10例冠状动脉正常的受试者中，对冠状动脉内注射2毫升超声处理的泛影葡胺-76与5至10毫升未超声处理的泛影葡胺-76的心电图和血流动力学效应进行了比较。两毫升超声处理的泛影葡胺在超声心动图检查期间可提供最佳心肌显影，而冠状动脉造影则需要5至10毫升泛影葡胺。在冠状动脉造影期间，与基线和心肌对比超声心动图相比，心率下降，PR和QT间期以及QRS时限增加（p<0.01）。同样，常规冠状动脉造影期间主动脉压和左心室压力一阶导数（dP/dt）的下降明显（p<0.01）大于心肌对比超声心动图期间。心肌对比超声心动图和冠状动脉造影期间左心室舒张末期或肺毛细血管楔压的变化相似。心肌对比超声心动图和冠状动脉造影之间心电图和血流动力学变化的持续时间没有显著差异。结论是冠状动脉内注射2毫升超声处理的泛影葡胺-76可提供最佳心肌显影。它在人体中是安全的，产生的短暂心电图和血流动力学改变比常规冠状动脉造影时所见的改变要轻。
