Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
Instituto de Pesquisas Clínicas Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
J Infect Dis. 2021 Jul 2;224(1):101-108. doi: 10.1093/infdis/jiab066.
Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, and causes single and coinfections in the populations of tropical countries.
The infection rate, viral abundance (VA), vector competence (VC), disseminated infection, and survival rate were recorded after single and multiple infections of the vector with 15 combinations of chikungunya, dengue, Zika, and yellow fever arboviruses.
Infection rates were 100% in all single and multiple infection experiments, except in 1 triple coinfection that presented a rate of 50%. The VC and disseminated infection rate varied from 100% (in single and quadruple infections) to 40% (in dual and triple infections). The dual and triple coinfections altered the VC and/or VA of ≥1 arbovirus. The highest viral VAs were detected for a single infection with chikungunya. The VAs in quadruple infections were similar when compared with each respective single infection. A decrease in survival rates was observed in a few combinations.
A. aegypti was able to host all single and multiple arboviral coinfections. The interference of the chikungunya virus suggests that distinct arbovirus families may have a significant role in complex coinfections.
埃及伊蚊是传播虫媒病毒的高效媒介，如基孔肯雅热、登革热、寨卡和黄热病病毒，并在热带国家的人群中引起单一和混合感染。
在对该媒介进行 15 种基孔肯雅热、登革热、寨卡和黄热病虫媒病毒的单一和多重感染后，记录了感染率、病毒丰度（VA）、媒介效能（VC）、播散感染和存活率。
除了三重混合感染的感染率为 50%外，所有单一和多重感染实验的感染率均为 100%。VC 和播散感染率从 100%（单一和四重感染）到 40%（双重和三重感染）不等。双重和三重混合感染改变了至少一种虫媒病毒的 VC 和/或 VA。单一感染基孔肯雅热时检测到的病毒 VA 最高。与各自的单一感染相比，四重感染的 VA 相似。少数组合的存活率下降。
埃及伊蚊能够携带所有的单一和多重虫媒病毒混合感染。基孔肯雅热病毒的干扰表明，不同的虫媒病毒家族在复杂的混合感染中可能具有重要作用。
