Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188522. doi: 10.1016/j.bbcan.2021.188522. Epub 2021 Feb 2.
In recent years, the most widely distributed eukaryotic messenger RNA (mRNA) modification, N6-methyladenosine (m6A), has received a large amount of interest, in part due to the development and advances of high-throughput RNA sequencing. The effects of m6A mRNA on tumor progression have been the most widely studied, and large amounts of conflicting data have been reported due to differences in tumor contexts, cell types or cell states. The majority of these studies were related to the significance of m6A mRNA on tumor cells, including on proliferation, stemness, invasion capability, etc. However, it has been noted that tumorigenesis and tumor progression cannot occur without support from the tumor microenvironment (TME), which contains multiple types of stromal cells, such as infiltrating immune cells (IICs), vascular cells, mesenchymal stem cells (MSCs), cancer-associated fibroblasts (CAFs), and various environmental factors. Here, we summarized the contributions of abnormal m6A mRNA in stromal cells within the TME and described the effects of m6A mRNA on TME remodeling.
近年来，分布最广泛的真核信使 RNA（mRNA）修饰——N6-甲基腺苷（m6A）——受到了大量关注，部分原因是高通量 RNA 测序技术的发展和进步。m6A mRNA 对肿瘤进展的影响是研究最多的，由于肿瘤背景、细胞类型或细胞状态的差异，报道了大量相互矛盾的数据。这些研究大多与 m6A mRNA 对肿瘤细胞的重要性有关，包括增殖、干性、侵袭能力等。然而，人们注意到，如果没有肿瘤微环境（TME）的支持，肿瘤发生和肿瘤进展是不可能发生的，TME 中包含多种基质细胞，如浸润免疫细胞（IICs）、血管细胞、间充质干细胞（MSCs）、癌相关成纤维细胞（CAFs）和各种环境因素。在这里，我们总结了 TME 中基质细胞中异常 m6A mRNA 的贡献，并描述了 m6A mRNA 对 TME 重塑的影响。
