Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100085, China.
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Sci Total Environ. 2021 Jun 1;771:145450. doi: 10.1016/j.scitotenv.2021.145450. Epub 2021 Jan 28.
The presence of pharmaceutical residues in aquatic ecosystems is a worldwide problem that may pose serious threats and challenges to the environment, especially to the safety of aquatic biota. In the present study, we investigated the effects of 14 environmentally relevant pharmaceutical compounds on individual and collective-related behaviours in juvenile zebrafish (Danio rerio) for 21 days. The tested concentrations of the compounds spanned three orders of magnitude. This study also compared the potential risks of these compounds in Chinese surface waters based on the data on their toxic effects or only on behavioural effects. In the case of individual behaviours, most antidepressants, but not anti-inflammatory agents or blood lipid-lowering agents, decreased fish locomotor activity (LMA) and individual social activity (IDS); however, all three classes of compounds induced significant disruptions in the light/dark transition locomotor response (LMR-L/D) performance, even at lower treatment levels (0.1-1 μg/L). Furthermore, collective behaviour (CLB) analysis suggested that most of the compounds significantly altered the group sociability of fish and frequently occurred at environmentally relevant concentrations. Finally, a risk assessment suggested that the presence of ibuprofen, fluoxetine, and venlafaxine in the surface waters of China poses a relatively high risk to fish, regardless of the risk ranking based on the data of the toxic or behavioural effects.
药物残留存在于水生生态系统中是一个全球性的问题，可能对环境，特别是水生生物群的安全构成严重威胁和挑战。在本研究中，我们研究了 14 种环境相关的药物化合物对幼斑马鱼（Danio rerio）个体和集体相关行为的影响，为期 21 天。测试的化合物浓度跨越了三个数量级。本研究还根据这些化合物的毒性效应或仅基于行为效应的数据，比较了它们在中国地表水中的潜在风险。对于个体行为，大多数抗抑郁药，但不是抗炎药或降血脂药，降低了鱼的运动活动（LMA）和个体社交活动（IDS）；然而，所有这三类化合物在较低的处理水平（0.1-1μg/L）下也会显著破坏光/暗转换运动反应（LMR-L/D）性能。此外，集体行为（CLB）分析表明，大多数化合物显著改变了鱼的群体社交性，并且经常在环境相关浓度下发生。最后，风险评估表明，在中国地表水中存在布洛芬、氟西汀和文拉法辛对鱼类构成相对较高的风险，而不论基于毒性或行为效应数据的风险排名如何。
