慢性阻塞性肺疾病人群中不宁腿综合征的随访研究。

A follow-up study on restless legs syndrome in chronic obstructive pulmonary disease population.

机构信息

Nursing Department, Duy Tan University, Da Nang, Vietnam.

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; Department of Health Services Administration, China Medical University College of Public Health, Taichung, Taiwan; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan.

出版信息

Sleep Med. 2021 Apr;80:9-15. doi: 10.1016/j.sleep.2021.01.016. Epub 2021 Jan 15.

DOI:10.1016/j.sleep.2021.01.016

PMID:33545488

Abstract

BACKGROUND

Restless legs syndrome (RLS) is prevalent in patients with chronic obstructive pulmonary disease (COPD). No large population-based cohort study has assessed the relationship. We evaluated the incidence of RLS among COPD patients by sociodemographic status (SES) and comorbidity using insurance claims data of Taiwan.

METHODS

From the database, we established a cohort consisting of 77,831 individuals aged ≥ 20 years newly diagnosed with COPD from 2000 to 2013. We also identified same number of individuals without COPD as the comparison cohort, frequency matched by sex, age and index year. Both cohorts were followed up to the end of 2013 to estimate the incidence and hazard ratio (HR) of developing RLS.

RESULTS

The incidence of RLS was 2.2-fold higher in COPD patients than in those free of COPD (6.67 and 3.08 per 10,000 person-years), with an adjusted HR (aHR) 1.68 (95% CI 1.41-2.01) after controlling for covariates. The incidence rates in both cohorts increased with age and higher in low socioeconomic group. The risk of RLS increased further among COPD patients with additional comorbidities. Compared to those without COPD and comorbidity, the aHR was 7.93 (95% CI 1.11-57.8) for those with iron deficiency, 3.95 (96% CI 1.92-8.13) with Parkinson's disease, 2.85 (95% CI 1.05-7.72) with polyneuropathy, or 1.81 (95% CI 1.14-2.87) with diabetes.

CONCLUSION

Patients with COPD are at an increased risk of developing RLS regardless of gender, age and occupation. The COPD patients with comorbidities should be particularly cautious about the RLS risk.

摘要

背景

不宁腿综合征（RLS）在慢性阻塞性肺疾病（COPD）患者中较为常见。尚无大型基于人群的队列研究评估两者之间的关系。我们使用台湾的保险理赔数据，评估了社会人口统计学地位（SES）和合并症对 COPD 患者 RLS 发生率的影响。

方法

我们从数据库中建立了一个队列，该队列由 2000 年至 2013 年期间新诊断为 COPD 的 77831 名年龄≥20 岁的个体组成。我们还确定了数量相同的无 COPD 个体作为对照队列，按性别、年龄和指数年进行频数匹配。两个队列均随访至 2013 年底，以估计 RLS 的发生率和发病风险比（HR）。

结果

COPD 患者的 RLS 发生率是无 COPD 患者的 2.2 倍（每 10000 人年 6.67 例和 3.08 例），调整后的 HR（aHR）为 1.68（95%CI 1.41-2.01），校正了协变量。两个队列的发病率均随年龄增长而增加，且 SES 较低的人群发病率更高。在合并其他合并症的 COPD 患者中，RLS 的风险进一步增加。与无 COPD 和无合并症的患者相比，缺铁患者的 aHR 为 7.93（95%CI 1.11-57.8），帕金森病患者为 3.95（96%CI 1.92-8.13），多发性神经病患者为 2.85（95%CI 1.05-7.72），糖尿病患者为 1.81（95%CI 1.14-2.87）。