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Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.不宁腿综合征和周期性肢体运动障碍的治疗：美国睡眠医学学会临床实践指南
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Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute.不宁腿综合征多巴胺能增强的诊断标准：马克斯·普朗克研究所世界睡眠医学协会-国际不宁腿综合征研究小组共识会议报告
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Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation.不宁腿综合征/Willis-Ekbom病一线治疗、多巴胺能药物增敏的预防和治疗指南：国际不宁腿综合征研究组、欧洲不宁腿综合征参考网络及不宁腿综合征基金会联合特别工作组
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Clinics (Sao Paulo). 2010 May;65(5):548-54. doi: 10.1590/S1807-59322010000500013.
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[When the legs have to keep moving at night--the restless legs syndrome].[当双腿在夜间不得不持续移动时——不宁腿综合征]
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Motor hyperactivity of the iron-deficient rat - an animal model of restless legs syndrome.缺铁型大鼠的运动过度——不宁腿综合征的动物模型。
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Restless legs syndrome.不宁腿综合征
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[Update on restless legs syndrome].[不宁腿综合征的最新进展]
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Sleep Medicine-What's in a Name?睡眠医学——名称里有什么？
J Sleep Res. 2025 Oct;34(5):e70150. doi: 10.1111/jsr.70150. Epub 2025 Jul 19.

本文引用的文献

1
Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.不宁腿综合征和周期性肢体运动障碍的治疗：美国睡眠医学学会临床实践指南
J Clin Sleep Med. 2025 Jan 1;21(1):137-152. doi: 10.5664/jcsm.11390.
2
Rethinking clinical trials in restless legs syndrome: A roadmap.重新思考不宁腿综合征的临床试验：路线图。
Sleep Med Rev. 2024 Oct;77:101978. doi: 10.1016/j.smrv.2024.101978. Epub 2024 Jul 18.
3
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.不宁腿综合征的全基因组荟萃分析为遗传结构、疾病生物学和风险预测提供了见解。
Nat Genet. 2024 Jun;56(6):1090-1099. doi: 10.1038/s41588-024-01763-1. Epub 2024 Jun 5.
4
Clinical efficacy and safety of intravenous ferric carboxymaltose for treatment of restless legs syndrome: a multicenter, randomized, placebo-controlled clinical trial.静脉注射羧甲麦芽糖铁治疗不安腿综合征的临床疗效和安全性：一项多中心、随机、安慰剂对照临床试验。
Sleep. 2024 Jul 11;47(7). doi: 10.1093/sleep/zsae095.
5
A randomized double-blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the treatment of restless legs syndrome in patients with iron deficiency anemia.一项随机、双盲、初步研究，旨在评估静脉铁剂与口服铁剂治疗缺铁性贫血伴不安腿综合征患者的疗效、安全性和耐受性。
Am J Hematol. 2024 Jun;99(6):1077-1083. doi: 10.1002/ajh.27290. Epub 2024 Mar 13.
6
Restless legs syndrome in people with multiple sclerosis: An updated systematic review and meta-analyses.多发性硬化症患者的不宁腿综合征：更新的系统评价和荟萃分析。
Mult Scler Relat Disord. 2021 Nov;56:103275. doi: 10.1016/j.msard.2021.103275. Epub 2021 Sep 22.
7
Thyroid Dysfunction and Sleep Disorders.甲状腺功能紊乱与睡眠障碍。
Front Endocrinol (Lausanne). 2021 Aug 24;12:725829. doi: 10.3389/fendo.2021.725829. eCollection 2021.
8
A follow-up study on restless legs syndrome in chronic obstructive pulmonary disease population.慢性阻塞性肺疾病人群中不宁腿综合征的随访研究。
Sleep Med. 2021 Apr;80:9-15. doi: 10.1016/j.sleep.2021.01.016. Epub 2021 Jan 15.
9
Bidirectional association between irritable bowel syndrome and restless legs syndrome: a systematic review and meta-analysis.肠易激综合征与不安腿综合征之间的双向关联：系统评价和荟萃分析。
Sleep Med. 2021 Jan;77:104-111. doi: 10.1016/j.sleep.2020.12.002. Epub 2020 Dec 4.
10
Functional connectivity and topology in patients with restless legs syndrome: a case-control resting-state functional magnetic resonance imaging study.静息态功能磁共振成像研究：不安腿综合征患者的功能连接和拓扑结构。
Eur J Neurol. 2021 Feb;28(2):448-458. doi: 10.1111/ene.14577. Epub 2020 Nov 5.

Restless legs syndrome: abbreviated guidelines by the German sleep society and the German neurological society.

作者信息

Trenkwalder Claudia, Stefani Ambra, Bachmann Cornelius G, Maihöfner Christian, Mathis Johannes, Muntean Lucia, Mollin Julian, Paulus Joachim, Heidbreder Anna

机构信息

Paracelsus-Elena Klinik, Center of Parkinsonism and Movement Disorders, Klinikstraße 16, Kassel, Germany.

Department of Neurosurgery, University Medical Center, Goettingen, Germany.

出版信息

Neurol Res Pract. 2024 Nov 6;6(1):53. doi: 10.1186/s42466-024-00353-0.

DOI:10.1186/s42466-024-00353-0
PMID:39501372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11539677/
Abstract
摘要