School of Sports and Social Sciences, Shandong Sport University, Jinan, China.
College of Physical Education of Jiangsu Normal University, Xuzhou, China.
Ann Palliat Med. 2021 Jan;10(1):340-349. doi: 10.21037/apm-20-2267.
Circadian rhythm disorder caused by lack of sleep, day-night reversal, or staying up late, can cause irreparable damage to the body, a significant increase in both the systolic and diastolic blood pressure of women in this age bracket. The purpose of this study was to investigate the effects of circadian disruption on body composition and insulin resistance in women aged 31-40 years.
Thirty female with circadian rhythm disorder and employed of the Foot Bath Club in Qufu city were selected as the research subjects, and a body composition analyzer was used to test the subjects' body composition using bioelectrical impedance analysis. Serum melatonin (MT) levels were determined by enzyme-linked immunosorbent assay (ELISA), and blood glucose and insulin levels were detected by glucose oxidase and chemiluminescence assays, respectively.
The results showed that circadian rhythm disorder caused a rise in blood pressure, whereas body water, especially lower limb water and intra- and extracellular fluid, decreased significantly. Circadian disruption also resulted in decreased muscle mass, protein quality, and melatonin production, but increased visceral fat levels and insulin resistance.
This study has demonstrated that circadian rhythm disorders are responsible for changes in body composition, melatonin levels, and insulin resistance in women aged 31-40 years and may be a risk factor for cardiovascular disease and diabetes.
睡眠不足、昼夜颠倒或熬夜等导致的昼夜节律紊乱会对身体造成不可挽回的损害，使该年龄段女性的收缩压和舒张压显著升高。本研究旨在探讨昼夜节律紊乱对 31-40 岁女性身体成分和胰岛素抵抗的影响。
选择曲阜市足浴俱乐部的 30 名患有昼夜节律紊乱的女性作为研究对象，使用身体成分分析仪通过生物电阻抗分析测试受试者的身体成分。采用酶联免疫吸附试验（ELISA）测定血清褪黑素（MT）水平，葡萄糖氧化酶法和化学发光法分别检测血糖和胰岛素水平。
结果表明，昼夜节律紊乱会导致血压升高，而身体水分，特别是下肢水分和细胞内外液会显著减少。昼夜节律紊乱还会导致肌肉质量、蛋白质质量和褪黑素生成减少，而内脏脂肪水平和胰岛素抵抗增加。
本研究表明，昼夜节律紊乱会导致 31-40 岁女性身体成分、褪黑素水平和胰岛素抵抗的变化，可能是心血管疾病和糖尿病的危险因素。
