Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Life Sci. 2020 Dec 1;262:118512. doi: 10.1016/j.lfs.2020.118512. Epub 2020 Sep 30.
Circadian rhythms play an important role in a wide range of human physiology and pathology. Individuals increasingly experience situations such as night-shift work schedules, likely leading to circadian disruption. Recent studies have also demonstrated that patients with other diseases often show symptoms of circadian disruption as manifested by the sleep-wake cycle and other biological rhythms. Circadian disruption often results in changes to the phase, period, and amplitude of the sleep-wake cycle, melatonin rhythm, and core body temperature. Several cardiometabolic, psychiatric, and neurodegenerative diseases are closely related to circadian disruption. Several interventions are also available, including phototherapy, exogenous melatonin, and exercise. The cumulative findings suggest that circadian disruption can increase risk for some cardiometabolic diseases. Circadian disruption also acts as a concomitant symptom of several psychiatric and neurodegenerative diseases. More attention should be paid to evaluating the impact of circadian disruption on these related diseases, as well as the benefits of the mitigation interventions for both circadian disruption and related diseases.
昼夜节律在广泛的人类生理学和病理学中发挥着重要作用。人们越来越多地经历夜班工作等情况，可能导致昼夜节律紊乱。最近的研究还表明，其他疾病患者通常表现出昼夜节律紊乱的症状，如睡眠-觉醒周期和其他生物节律。昼夜节律紊乱通常会导致睡眠-觉醒周期、褪黑素节律和核心体温的相位、周期和幅度发生变化。一些心血管代谢、精神和神经退行性疾病与昼夜节律紊乱密切相关。也有几种干预措施可用，包括光疗、外源性褪黑素和运动。累积的研究结果表明，昼夜节律紊乱会增加一些心血管代谢疾病的风险。昼夜节律紊乱也作为几种精神和神经退行性疾病的伴随症状出现。应该更加关注评估昼夜节律紊乱对这些相关疾病的影响，以及减轻干预措施对昼夜节律紊乱和相关疾病的益处。
