Zaroukian M H, Kashyap G H, Wentworth B B
Department of Medicine, College of Human Medicine, Michigan State University, East Lansing 48824-1315.
Am J Med Sci. 1988 Mar;295(3):218-22. doi: 10.1097/00000441-198803000-00011.
Respiratory syncytial virus (RSV) infection, an important and sometimes lethal disease of infants and children, generally causes a milder and self-limited syndrome of cough, nasal congestion and fever in adults. While some evidence suggests that RSV may be responsible for more serious respiratory illness in the elderly and chronically ill, it has not been shown to cause life-threatening respiratory tract disease in previously healthy adults. This report describes a previously healthy woman who experienced the acute onset of right lower lobe pneumonia which rapidly progressed to the adult respiratory distress syndrome (ARDS). Acute and convalescent serology showed RSV was the cause of the respiratory tract illness. Michigan Department of Public Health records revealed six additional cases of adult bilateral pneumonia with diagnostic antibody titers to RSV, with or without coinfection with a second organism. These data suggest that RSV may be an under-recognized cause of lower respiratory tract disease in adults.
呼吸道合胞病毒（RSV）感染是婴幼儿的一种重要且有时致命的疾病，而在成人中通常引起较轻的、自限性的咳嗽、鼻塞和发热综合征。虽然有证据表明RSV可能导致老年人和慢性病患者出现更严重的呼吸道疾病，但尚未证明它会在既往健康的成人中引起危及生命的呼吸道疾病。本报告描述了一名既往健康的女性，她突发右下叶肺炎，并迅速进展为成人呼吸窘迫综合征（ARDS）。急性期和恢复期血清学检查显示RSV是呼吸道疾病的病因。密歇根州公共卫生部记录显示，另外还有6例成人双侧肺炎病例，其针对RSV的诊断性抗体滴度呈阳性，伴有或不伴有第二种病原体的合并感染。这些数据表明，RSV可能是成人下呼吸道疾病的一个未被充分认识的病因。
