Gynecology Department, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Medicine (Baltimore). 2021 Jan 22;100(3):e23892. doi: 10.1097/MD.0000000000023892.
In recent years, several reports have tried to prove this connection between rs1800872 polymorphism in interleukin-10 and cervical cancer among different populations, but the results are debatable. Thus, we collected all the published literature and conducted an integrated meta-analysis, which provided better evidence-based medicine for the relationship between rs1800872 polymorphism in interleukin-10 and risk of cervical cancer.
We systematically performed our search on PubMed, EMBASE, Web of Science, WanFang database, and CNKI for all papers related to this research, published up to August 1, 2020. Summary odds ratios (OR) with 95% confidence interval (95% CI) were calculated in allelic, homozygous, heterozygous, dominant, and recessive model to appraise the association.
The meta-analysis included 8 studies containing 1393 cervical cancer cases and 1307 controls. The aggregate data under heterozygous model and dominant inheritance model (OR = 0.66, 95% CI: 0.55--0.80) indicated a significant association between rs1800872 and the low risk of cervical cancer in the entire population. And the aggregated data under the dominant inheritance model shows that rs1800872 is significantly associated with the reduction in the risk of cervical tumors in the entire population.
Our conclusion is that the AC/AA + AC variant of Rs1800872 indicates a protective effect in the development of cervical cancer.
近年来，已有数项研究报告试图在不同人群中证明白细胞介素-10 基因 rs1800872 多态性与宫颈癌之间存在关联，但结果存在争议。因此，我们收集了所有已发表的文献并进行了荟萃分析，为白细胞介素-10 基因 rs1800872 多态性与宫颈癌风险之间的关系提供了更好的循证医学证据。
我们系统地在 PubMed、EMBASE、Web of Science、万方数据库和中国知网（CNKI）上搜索了所有与本研究相关的论文，检索时间截至 2020 年 8 月 1 日。采用等位基因、纯合子、杂合子、显性和隐性模型计算汇总优势比（OR）及其 95%置信区间（95%CI），以评估相关性。
荟萃分析纳入了 8 项研究，共包含 1393 例宫颈癌病例和 1307 例对照。在杂合子模型和显性遗传模型下的汇总数据（OR=0.66，95%CI：0.55-0.80）表明，rs1800872 与整个人群中宫颈癌的低风险之间存在显著关联。显性遗传模型下的汇总数据表明，rs1800872 与整个人群中宫颈癌肿瘤风险的降低显著相关。
我们的结论是，Rs1800872 的 AC/AA+AC 变体表明其在宫颈癌发生发展中具有保护作用。
