• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多态性与宫颈癌风险的关联：荟萃分析。

Association of the Polymorphism and Cervical Cancer Risk: A Meta-Analysis.

机构信息

Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM), University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, Illinois 60611, USA.

出版信息

Genet Res (Camb). 2022 Jul 12;2022:2319161. doi: 10.1155/2022/2319161. eCollection 2022.

DOI:10.1155/2022/2319161
PMID:35919032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9296312/
Abstract

A literature review showed some discrepancies regarding the association of with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP of the gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the polymorphism of and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the polymorphism of the gene for the recessive model (OR = 1.30, 95% CI = 1.14-1.49), dominant model (OR = 1.36, 95% CI = 1.09-1.70), and additive model (OR = 1.25, 95% CI = 1.09-1.44). Regarding ethnicity, a significant association of the polymorphism of the gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with < 0.05. The polymorphism of the gene may be considered a risk factor for cervical cancer.

摘要

一篇文献综述显示，与宫颈癌风险相关的 基因存在一些差异。为了通过增加研究病例数量来更精确地分析数据，并通过考虑来自不同来源的结果来更可接受地推广，本荟萃分析针对探讨 基因 SNP 与宫颈癌风险之间关系的已发表研究进行。这项研究共纳入了 11 项研究，包括 4187 例病例和 3311 例对照，以调查 基因多态性与宫颈癌风险之间的关系。采用固定效应或随机效应模型进行汇总优势比（OR）分析。采用不一致性检验和漏斗图分别进行异质性和偏倚检验。总体分析显示， 基因的 多态性与宫颈癌的易感性增加有关，对于隐性模型（OR=1.30，95%CI=1.14-1.49）、显性模型（OR=1.36，95%CI=1.09-1.70）和加性模型（OR=1.25，95%CI=1.09-1.44）均如此。关于种族，对于所有遗传模型（隐性、显性和加性），亚洲人群中 基因的 多态性与宫颈癌风险增加显著相关，白种人群中隐性和加性模型也显著相关（均 < 0.05）。 基因的 多态性可能被视为宫颈癌的一个危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/7c52e5eaf836/GR2022-2319161.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/2a6796dc48fb/GR2022-2319161.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/a08d29e8b5f0/GR2022-2319161.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/3f833d14e008/GR2022-2319161.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/55fa9b0c9dd6/GR2022-2319161.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/6468c0763a3c/GR2022-2319161.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/7c52e5eaf836/GR2022-2319161.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/2a6796dc48fb/GR2022-2319161.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/a08d29e8b5f0/GR2022-2319161.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/3f833d14e008/GR2022-2319161.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/55fa9b0c9dd6/GR2022-2319161.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/6468c0763a3c/GR2022-2319161.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8787/9296312/7c52e5eaf836/GR2022-2319161.006.jpg

相似文献

1
Association of the Polymorphism and Cervical Cancer Risk: A Meta-Analysis.多态性与宫颈癌风险的关联：荟萃分析。
Genet Res (Camb). 2022 Jul 12;2022:2319161. doi: 10.1155/2022/2319161. eCollection 2022.
2
Interleukin 10 polymorphisms and cervical cancer risk: a meta-analysis.白细胞介素 10 多态性与宫颈癌风险：荟萃分析。
Int J Gynecol Cancer. 2013 Jan;23(1):126-33. doi: 10.1097/IGC.0b013e318274b1a2.
3
The interleukin-10 promoter polymorphism rs1800872 (-592C>A), contributes to cancer susceptibility: meta-analysis of 16,785 cases and 19,713 controls.白细胞介素-10 启动子多态性 rs1800872（-592C>A）与癌症易感性相关：16785 例病例和 19713 例对照的荟萃分析。
PLoS One. 2013;8(2):e57246. doi: 10.1371/journal.pone.0057246. Epub 2013 Feb 27.
4
Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer.白细胞介素-10基因-592C>A多态性与胃癌易感性
Genet Mol Res. 2014 Oct 31;13(4):8954-61. doi: 10.4238/2014.October.31.10.
5
Interleukin-10 gene -1082 G/A polymorphism in cervical cancer and cervical intraepithelial neoplasia: meta-analysis.白细胞介素-10基因-1082 G/A多态性与宫颈癌及宫颈上皮内瘤变的关系：荟萃分析
J Int Med Res. 2014 Dec;42(6):1193-201. doi: 10.1177/0300060514544388. Epub 2014 Oct 3.
6
Interleukin-10 -592C/A, but not -1082A/G promoter single nucleotide polymorphism, is associated with a decreased risk of colorectal cancer in an ethnic Kashmiri population: a case-control study.白细胞介素-10基因-592C/A单核苷酸多态性（而非-1082A/G启动子单核苷酸多态性）与克什米尔族人群结直肠癌风险降低相关：一项病例对照研究。
Eur J Cancer Prev. 2017 Nov;26(6):476-490. doi: 10.1097/CEJ.0000000000000370.
7
The -592C>A variation of IL-10 gene and susceptibility to chronic periodontitis: A genetic association study and in-silico analysis.白细胞介素-10基因-592C>A变异与慢性牙周炎易感性：一项遗传关联研究及电子分析
J Oral Biosci. 2021 Dec;63(4):378-387. doi: 10.1016/j.job.2021.09.005. Epub 2021 Sep 20.
8
Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis.白细胞介素-10-1082A>G、-819C>T 和-592C>A 多态性与慢性侵袭性牙周炎易感性的关联：系统评价和荟萃分析。
Inflamm Res. 2021 May;70(5):509-524. doi: 10.1007/s00011-021-01448-z. Epub 2021 Mar 5.
9
The association between rs1800872 polymorphism in interleukin-10 and risk of cervical cancer: A meta-analysis.白细胞介素-10 基因 rs1800872 多态性与宫颈癌风险的关联：一项荟萃分析。
Medicine (Baltimore). 2021 Jan 22;100(3):e23892. doi: 10.1097/MD.0000000000023892.
10
IL-10 gene polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.白细胞介素-10 基因多态性与系统性红斑狼疮易感性的关系：一项荟萃分析。
PLoS One. 2013 Jul 23;8(7):e69547. doi: 10.1371/journal.pone.0069547. Print 2013.

本文引用的文献

1
Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10.通过瞬时异位表达 CXCR4 和 IL10 增强间充质基质细胞的抗炎作用。
Stem Cell Res Ther. 2021 Feb 12;12(1):124. doi: 10.1186/s13287-021-02193-0.
2
The association between rs1800872 polymorphism in interleukin-10 and risk of cervical cancer: A meta-analysis.白细胞介素-10 基因 rs1800872 多态性与宫颈癌风险的关联：一项荟萃分析。
Medicine (Baltimore). 2021 Jan 22;100(3):e23892. doi: 10.1097/MD.0000000000023892.
3
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
4
Association study of IL10 gene polymorphisms (rs1800872 and rs1800896) with cervical cancer in the Bangladeshi women.IL10 基因多态性（rs1800872 和 rs1800896）与孟加拉国女性宫颈癌的关联研究。
Int Immunopharmacol. 2020 Dec;89(Pt B):107091. doi: 10.1016/j.intimp.2020.107091. Epub 2020 Oct 16.
5
IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer.白细胞介素-10 c.-592C>A（rs1800872）多态性与宫颈癌相关。
J Cancer Res Clin Oncol. 2020 Aug;146(8):1971-1978. doi: 10.1007/s00432-020-03256-0. Epub 2020 May 23.
6
The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province.白细胞介素 10 多态性对陕西省汉族女性乳腺癌易感性的影响。
PLoS One. 2020 May 7;15(5):e0232174. doi: 10.1371/journal.pone.0232174. eCollection 2020.
7
Association of IL-10 (rs1800872) and IL-4R (rs1805010) polymorphisms with cervical intraepithelial lesions and cervical carcinomas.白细胞介素-10（rs1800872）和白细胞介素-4受体（rs1805010）基因多态性与宫颈上皮内瘤变及宫颈癌的相关性
J BUON. 2020 Jan-Feb;25(1):132-140.
8
Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.白细胞介素-10 启动子中的遗传多态性与非裔美国人的吸烟和前列腺癌风险相关。
Anticancer Res. 2020 Jan;40(1):27-34. doi: 10.21873/anticanres.13923.
9
Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions.《可信系统评价的更新指南：干预措施系统评价的新版Cochrane手册》
Cochrane Database Syst Rev. 2019 Oct 3;10(10):ED000142. doi: 10.1002/14651858.ED000142.
10
Interaction Between Susceptibility Loci in and Genes, and High-risk HPV Infection on the Risk of Cervical Precancerous Lesions in Chinese Population.及 基因中的易感位点与高危型 HPV 感染在中国人群中对宫颈癌前病变发病风险的交互作用。
Cancer Prev Res (Phila). 2019 Jan;12(1):57-66. doi: 10.1158/1940-6207.CAPR-18-0177. Epub 2018 Nov 21.