Department of Biomedical Laboratory Science, TaeKyeung University, 65, Danbuk 1-gil, Jain-myeon, Gyeongsan-si, Gyeongsangbuk-do 38547, Korea.
APROGEN, Inc., 545, Dunchon-daero, Jungwon-gu, Seongnam-si, Gyeonggi-do 13215, Korea.
Molecules. 2021 Feb 3;26(4):779. doi: 10.3390/molecules26040779.
Mealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expressions of wound healing factors such as alpha-smooth muscle actin (α-SMA), collagen-1 (COL-1) and vascular endothelial growth factor (VEGF) in fibroblast cells. The tube formation and migration of endothelial cells were promoted through the activation of VEGF/VEGF receptor-2 (VEGFR-2)-mediated downstream signals including AKT, extracellular signal-regulated kinase (ERK) and p38 by MWO-stimulated fibroblasts for angiogenesis. Moreover, we confirmed that MWO promoted skin wound repair by collagen synthesis, re-epithelialization and angiogenesis in an in vivo excisional wound model. These results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds.
黄粉虫及其油脂（MWO）已被报道具有影响抗氧化、抗凝血、抗脂肪生成和抗炎活性的作用。然而，MWO 在伤口愈合中的功能尚不清楚。在这项研究中，我们发现 MWO 可诱导成纤维细胞的迁移，并上调与伤口愈合相关的基因，如α-平滑肌肌动蛋白（α-SMA）、胶原蛋白-1（COL-1）和血管内皮生长因子（VEGF）的表达。MWO 刺激的成纤维细胞通过激活血管内皮生长因子/血管内皮生长因子受体-2（VEGFR-2）介导的下游信号，如 AKT、细胞外信号调节激酶（ERK）和 p38，促进血管生成过程中内皮细胞的管形成和迁移。此外，我们还证实，MWO 可通过促进胶原蛋白合成、上皮再形成和血管生成，在体内切口模型中促进皮肤伤口修复。这些结果表明，MWO 可能具有作为治疗皮肤创伤的治疗剂的潜力。
