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大脑中银的积累导致哺乳动物认知障碍。

Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain.

作者信息

Antsiferova Anna A, Kopaeva Marina Yu, Kochkin Vyacheslav N, Kashkarov Pavel K, Kovalchuk Mikhail V

机构信息

National Research Center, Kurchatov Institute, 1, Akademika Kurchatova sq., 123182 Moscow, Russia.

Moscow Institute of Physics and Technologies, 9, Institutskii Lane, Moscow Region, 141700 Dolgoprudny, Russia.

出版信息

Toxics. 2021 Feb 3;9(2):30. doi: 10.3390/toxics9020030.

DOI:10.3390/toxics9020030
PMID:33546349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7913520/
Abstract

The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.

摘要

研究了每日长期给予银纳米颗粒对模型哺乳动物认知功能的影响。通过高精度且具有代表性的中子活化分析，研究了银在小鼠全脑以及海马体、小脑、皮质和残余脑组织中的蓄积情况，并进行了组织学研究。在此，我们表明，银纳米颗粒在大脑及其亚区域（如海马体、小脑和皮质）中的蓄积，通过干扰海马体细胞完整性，以逐步的方式导致了长期记忆障碍。三种不同的方法使我们能够观察到这一现象并发现其发生的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/9f97030b220c/toxics-09-00030-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/eb25ab5fe692/toxics-09-00030-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/9fac962f76f6/toxics-09-00030-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/76d0bcf6af48/toxics-09-00030-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/c030e3beedc6/toxics-09-00030-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/63eb1af479c9/toxics-09-00030-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/5de0c78b28c9/toxics-09-00030-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/9f97030b220c/toxics-09-00030-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/eb25ab5fe692/toxics-09-00030-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/9fac962f76f6/toxics-09-00030-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/76d0bcf6af48/toxics-09-00030-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/c030e3beedc6/toxics-09-00030-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/63eb1af479c9/toxics-09-00030-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/5de0c78b28c9/toxics-09-00030-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7178/7913520/9f97030b220c/toxics-09-00030-g006.jpg

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