Phytochemistry and Healthy Foods Lab., Group of Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, University Campus of Espinardo, Edif. 25, E-30100, Murcia, Spain.
Phytochemistry and Healthy Foods Lab., Group of Quality, Safety, and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, University Campus of Espinardo, Edif. 25, E-30100, Murcia, Spain.
Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):930-938. doi: 10.1016/j.numecd.2020.11.016. Epub 2020 Nov 24.
The overconsumption of sucrose is closely related to sugar-sweetened beverages and one of the main factors associated with the increase of metabolic diseases, such as type 2 diabetes, obesity, and insulin resistance. So, the addition of alternative sweeteners to new fruit-based drinks could contribute to minimizing the incidence or severity of these pathologies. Nevertheless, current knowledge on the influence of these additives on the bioactive compounds present in these beverages is still scarce.new-onset hypertension, but few data were published in Asian. We aimed to investigate the association of lipid profiles with new-onset hypertension in a Chinese community-based non-hypertensive cohort without lipid-lowering treatment (n = 1802).
Hence, to contribute to the understanding of this issue, the plasma concentration of phenolic compounds (anthocyanins and flavanones), after the ingestion of a new maqui-citrus-based beverage, supplemented with sucrose (natural high caloric), stevia (natural non-caloric), or sucralose (artificial non-caloric), was evaluated as evidence of their intestinal absorption and metabolism previous to renal excretion. The beverages were ingested by volunteers (n = 20) and the resulting phenolic metabolites in plasma were analyzed by UHPLC-ESI-MS/MS. A total of 13 metabolites were detected: caffeic acid sulfate, caffeic acid glucuronide, 3,4-dihydroxyfenylacetic, 3,4-dihydroxyfenylacetic sulfate. 3,4-dihydroxyfenylacetic acid di-sulfate, 3,4-dihydroxyfenylacetic di-glucuronide, 3,4-dihydroxyfenylacetic glucuronide-sulfate, trans-ferulic acid glucuronide, naringenin glucuronide, vanillic acid, vanillic acid sulfate, vanillic acid glucuronide-sulfate, and vanillic acid di-glucuronide, being recorded their maximum concentration after 30-60 min.
In general, sucralose provided the greatest absorption value for most of these metabolites, followed by stevia. Due to this, the present study proposes sucralose and stevia (non-caloric sweeteners) as valuable alternatives to sucrose (high caloric sweetener), to avoid the augmented risk of several metabolic disorders.
蔗糖的过度消耗与含糖饮料密切相关，是导致 2 型糖尿病、肥胖和胰岛素抵抗等代谢性疾病增加的主要因素之一。因此，在新型水果饮料中添加替代甜味剂可能有助于降低这些疾病的发病率或严重程度。然而，目前关于这些添加剂对饮料中生物活性化合物的影响的知识仍然很少。在亚洲发表的关于新发性高血压的研究数据较少。我们旨在调查在中国社区非高血压队列中，血脂谱与新发高血压的相关性，该队列未经降脂治疗（n=1802）。
因此，为了有助于理解这个问题，评估了志愿者摄入含有蔗糖（天然高热量）、甜菊糖（天然无热量）或三氯蔗糖（人工无热量）的新型马尔基西梅柑橘饮料后，血浆中酚类化合物（花色苷和黄烷酮）的浓度，以证明其在肾排泄前的肠道吸收和代谢。志愿者（n=20）摄入了这些饮料，并用 UHPLC-ESI-MS/MS 分析了血浆中的酚类代谢物。共检测到 13 种代谢物：硫酸咖啡酸、咖啡酸葡萄糖醛酸、3,4-二羟基苯乙酸、3,4-二羟基苯乙酸硫酸盐、3,4-二羟基苯乙酸二硫酸盐、3,4-二羟基苯乙酸二葡萄糖醛酸、3,4-二羟基苯乙酸葡萄糖醛酸硫酸盐、反式阿魏酸葡萄糖醛酸、柚皮苷葡萄糖醛酸、香草酸、香草酸硫酸盐、香草酸葡萄糖醛酸硫酸盐和香草酸二葡萄糖醛酸，记录到这些代谢物的最大浓度出现在 30-60 分钟后。
总的来说，大多数代谢物的吸收值以三氯蔗糖最高，其次是甜菊糖。因此，本研究提出三氯蔗糖和甜菊糖（非热量甜味剂）作为蔗糖（高热量甜味剂）的替代物，以避免多种代谢紊乱风险的增加。
