Lavoie J M, Lord M, Paulin A
Département d'Education Physique, Université de Montréal, Quebec, Canada.
Am J Physiol. 1988 Apr;254(4 Pt 2):R602-6. doi: 10.1152/ajpregu.1988.254.4.R602.
Metabolic effects of a selective hepatic vagotomy (HV) were investigated in nonfasted (N) and 24-h fasted (F) rats, at rest and immediately after a 50-min exercise period (26 m/min, 0% grade). In nonfasted rats, no significant differences between HV and sham-operated (SHM) groups were found in blood substrates [free fatty acids (FFA) or glucose], insulin, and muscle glycogen levels, either at rest or after exercise. In F rats, liver glycogen was almost completely depleted at rest. This depletion was associated with a significantly (P less than 0.05) lower plasma FFA concentration at rest in HV compared with SHM rats (mean +/- SE, 0.57 +/- 0.04 vs. 0.83 +/- 0.1 mmol/l). No differences in FFA levels were observed between the same two groups after the exercise period. Exercise, however, resulted in a 2.5 times greater glycogen breakdown in the soleus muscle of HV compared with SHM rats. Hepatic vagotomy in the F condition was also associated with lower resting and exercising insulin concentrations. It is concluded that HV, when followed by a 24-h fast, may influence metabolic substrate regulation at rest and to a certain extent during exercise. These data support the concept of the existence of hepatic glucoreceptors responsive to a decrease in liver glycogen content.
在非禁食（N）和禁食24小时（F）的大鼠中，研究了选择性肝迷走神经切断术（HV）对静息状态以及50分钟运动期（26米/分钟，0%坡度）后即刻的代谢影响。在非禁食大鼠中，无论是静息状态还是运动后，HV组和假手术（SHM）组在血液底物[游离脂肪酸（FFA）或葡萄糖]、胰岛素以及肌肉糖原水平方面均未发现显著差异。在禁食大鼠中，静息时肝糖原几乎完全耗尽。与SHM大鼠相比，HV大鼠静息时血浆FFA浓度显著降低（P<0.05）（均值±标准误，0.57±0.04 vs. 0.83±0.1毫摩尔/升）。运动期后，相同两组之间的FFA水平未观察到差异。然而，运动导致HV大鼠比目鱼肌糖原分解量比SHM大鼠高2.5倍。禁食状态下的肝迷走神经切断术还与较低的静息和运动胰岛素浓度相关。结论是，禁食24小时后进行HV，可能会影响静息状态下以及运动期间一定程度上的代谢底物调节。这些数据支持存在对肝糖原含量降低有反应的肝葡萄糖受体这一概念。
