Moran T H, McHugh P R
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Am J Physiol. 1988 Apr;254(4 Pt 2):R628-32. doi: 10.1152/ajpregu.1988.254.4.R628.
The quantitative relationship between cholecystokinin's (CCK) inhibitory actions on gastric emptying and feeding was examined in rats. CCK (1, 2, 4, or 8 micrograms/kg) inhibited both the gastric emptying (determined by the dye dilution method) and ingestion of a 0.5-kcal/ml glucose solution in a 30-min testing period in 20-h deprived male Sprague-Dawley rats. Comparisons of the inhibitions of gastric emptying and feeding across the dose range of CCK revealed two components of CCK satiety: one defined by a linear relationship between the gastric inhibitory and feeding inhibitory actions of CCK through a dose range of 1-4 micrograms/kg, which accounted for 64% of the variability in the satiety action of CCK, and a second that appeared to be independent of the gastric inhibitory action of CCK.
在大鼠中研究了胆囊收缩素（CCK）对胃排空和进食的抑制作用之间的定量关系。在20小时未进食的雄性斯普拉格-道利大鼠的30分钟测试期内，CCK（1、2、4或8微克/千克）抑制胃排空（通过染料稀释法测定）以及0.5千卡/毫升葡萄糖溶液的摄取。在CCK的剂量范围内对胃排空和进食抑制作用的比较揭示了CCK饱腹感的两个组成部分：一个由CCK在1-4微克/千克剂量范围内的胃抑制作用和进食抑制作用之间的线性关系定义，这占CCK饱腹感作用变异性的64%，另一个似乎与CCK的胃抑制作用无关。
