Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Bronchopulmonary Dysplasia Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
J Perinatol. 2021 Apr;41(4):707-717. doi: 10.1038/s41372-021-00929-7. Epub 2021 Feb 5.
Bronchopulmonary dysplasia (BPD) is a complex and serious cardiopulmonary morbidity in infants who are born preterm. Despite advances in clinical care, BPD remains a significant source of morbidity and mortality, due in large part to the increased survival of extremely preterm infants. There are few strong early prognostic indicators of BPD or its later outcomes, and evidence for the usage and timing of various interventions is minimal. As a result, clinical management is often imprecise. In this review, we highlight cutting-edge methods and findings from recent pulmonary imaging research that have high translational value. Further, we discuss the potential role that various radiological modalities may play in early risk stratification for development of BPD and in guiding treatment strategies of BPD when employed in varying severities and time-points throughout the neonatal disease course.
支气管肺发育不良(BPD)是早产儿患有的一种复杂且严重的心肺疾病。尽管临床护理有所进步,但由于极早产儿的存活率增加,BPD 仍然是发病率和死亡率的重要原因。目前,BPD 或其后期结果的早期预后指标很少,并且各种干预措施的使用和时机的证据也很少。因此,临床管理通常不够精确。在这篇综述中,我们重点介绍了最近肺部成像研究中的前沿方法和发现,这些研究具有很高的转化价值。此外,我们还讨论了各种影像学方式在 BPD 发展的早期风险分层以及在整个新生儿疾病过程中在不同严重程度和时间点应用时指导 BPD 治疗策略方面可能发挥的作用。