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评价北美青少年择期接受减肥手术的趋势、特点和结果。

Evaluation of the Trends, Characteristics, and Outcomes in North American Youth Undergoing Elective Bariatric Surgery.

机构信息

Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Department of Pediatrics, UUniversity of Alberta, Edmonton, AB, Canada.

出版信息

Obes Surg. 2021 May;31(5):2180-2187. doi: 10.1007/s11695-021-05248-6. Epub 2021 Feb 6.

Abstract

BACKGROUND

Severe obesity is increasingly common in youth and young adults, but outcomes following bariatric surgery remain largely unknown. The purpose of this study was to examine the trends, clinical characteristics, and postoperative outcomes of youth who underwent bariatric surgery.

METHODS

This retrospective cohort study was conducted using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) data registry from 2015 to 2018 inclusive. All youth and young adults aged 15-24 who underwent elective sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) were included. Bivariate analysis of trends, clinical characteristics, and postoperative outcomes was performed using Chi-squared tests for categorical variables and independent two sample t test for continuous variables. Multivariable logistic regression modeling was used to determine patient and operative factors predictive of serious complications.

RESULTS

A total of 21,592 youth and young adults underwent bariatric surgery during the study time frame, representing 3.7% of total cases (n = 583,567) within the MBSAQIP. The cohort had a mean age of 21.5 ± 2.0 years and a mean BMI of 47.2 ± 8.0 kg/m and were predominantly female (84%). A relatively constant number of youth and young adult cases per hospital were observed over time (7.4 cases/center in 2015 vs. 6.7 cases/center in 2018). Overall, < 5% of cases required reoperation, reintervention, and readmission, or led to serious complications within 30 days of surgery. Multivariable logistic regression analysis identified RYGB as the single greatest independent predictor of serious complications (OR 3.1; 95% CI 2.58-3.64; p < 0.0001). Additional factors predictive of serious complications included female sex (OR 1.31; 95% CI 1.01-1.70; p = 0.04), sleep apnea (OR 1.27; 95% CI 1.02-1.58), and non-insulin-dependent diabetes (OR 1.35; 95% CI 1.04-1.75; p = 0.025).

CONCLUSION

Bariatric surgery in youth is safe but comprised only 3.7% of total MBSAQIP cases from 2015 to 2018. These data should serve as a call to government and healthcare agencies to develop policies and strategies that prioritize bariatric surgery for young people living with severe obesity.

摘要

背景

严重肥胖在青少年和年轻人中越来越普遍,但减重手术的结果仍知之甚少。本研究的目的是研究接受减重手术的青少年的趋势、临床特征和术后结果。

方法

本回顾性队列研究使用 2015 年至 2018 年期间的代谢和减重外科认证和质量改进计划(MBSAQIP)数据登记处进行。所有年龄在 15-24 岁之间接受选择性袖状胃切除术(SG)或 Roux-en-Y 胃旁路术(RYGB)的青少年和年轻人均包括在内。使用卡方检验对趋势、临床特征和术后结果进行分类变量的双变量分析,使用独立两样本 t 检验对连续变量进行分析。使用多变量逻辑回归模型确定预测严重并发症的患者和手术因素。

结果

在研究期间,共有 21592 名青少年和年轻人接受了减重手术,占 MBSAQIP 中总病例数(n=583567)的 3.7%。该队列的平均年龄为 21.5±2.0 岁,平均 BMI 为 47.2±8.0 kg/m,主要为女性(84%)。随着时间的推移,每个医院的青少年和年轻人病例数相对稳定(2015 年为 7.4 例/中心,2018 年为 6.7 例/中心)。总体而言,<5%的病例在手术后 30 天内需要再次手术、再次干预和再次入院,或导致严重并发症。多变量逻辑回归分析确定 RYGB 是严重并发症的唯一最大独立预测因素(OR 3.1;95%CI 2.58-3.64;p<0.0001)。预测严重并发症的其他因素包括女性(OR 1.31;95%CI 1.01-1.70;p=0.04)、睡眠呼吸暂停(OR 1.27;95%CI 1.02-1.58)和非胰岛素依赖型糖尿病(OR 1.35;95%CI 1.04-1.75;p=0.025)。

结论

青少年的减重手术是安全的,但在 2015 年至 2018 年期间,仅占 MBSAQIP 总病例数的 3.7%。这些数据应该促使政府和医疗保健机构制定政策和战略,优先考虑患有严重肥胖症的年轻人进行减重手术。

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