Fuster Laboratory of Cognitive Neuroscience, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
University of Louisville, Louisville, KY, USA.
Neuron. 2021 Mar 17;109(6):918-937. doi: 10.1016/j.neuron.2021.01.013. Epub 2021 Feb 5.
The superior colliculus is a conserved sensorimotor structure that integrates visual and other sensory information to drive reflexive behaviors. Although the evidence for this is strong and compelling, a number of experiments reveal a role for the superior colliculus in behaviors usually associated with the cerebral cortex, such as attention and decision-making. Indeed, in addition to collicular outputs targeting brainstem regions controlling movements, the superior colliculus also has ascending projections linking it to forebrain structures including the basal ganglia and amygdala, highlighting the fact that the superior colliculus, with its vast inputs and outputs, can influence processing throughout the neuraxis. Today, modern molecular and genetic methods combined with sophisticated behavioral assessments have the potential to make significant breakthroughs in our understanding of the evolution and conservation of neuronal cell types and circuits in the superior colliculus that give rise to simple and complex behaviors.
上丘是一个保守的感觉运动结构，它整合视觉和其他感觉信息以驱动反射性行为。尽管这方面的证据确凿且令人信服，但一些实验揭示了上丘在通常与大脑皮层相关的行为中的作用，例如注意力和决策。事实上，除了靶向控制运动的脑干区域的丘系输出，上丘还有上升投射将其与包括基底神经节和杏仁核在内的前脑结构连接起来，这突出表明上丘凭借其广泛的输入和输出，可以影响整个神经系统的处理过程。如今，现代分子和遗传方法结合复杂的行为评估，有可能在上丘中导致简单和复杂行为的神经元细胞类型和回路的进化和保守方面取得重大突破。
