Michie A R, Freeman R M, Dutton D A, Howie H B
Rutherglen Maternity Hospital, Glasgow.
Anaesthesia. 1988 Feb;43(2):96-9. doi: 10.1111/j.1365-2044.1988.tb05472.x.
Forty patients who underwent elective lower segment Caesarean section under subarachnoid anaesthesia received either 2.0 ml 0.5% cinchocaine in 6% dextrose or 2.5 ml 0.5% bupivacaine in 8% dextrose via a 26-gauge needle with the patient in the left lateral position. Onset time was rapid in both groups and the distribution of maximum ascent of sensory analgesia was T1-T6. Efficacy of analgesia was greater in the bupivacaine group, although the duration of both sensory and motor blockade was shorter than following cinchocaine. There were no significant differences between the two groups either in the incidence and severity of complications or in the condition of the neonates. The high incidence (50-65%) and often profound extent of hypotension seen throughout the trial, confirm the ineffectiveness of crystalloid preload of 1500 ml as a single prophylaxis against hypotension.
40例在蛛网膜下腔麻醉下行择期下段剖宫产术的患者，通过26G穿刺针，在患者左侧卧位时，分别接受2.0 ml含6%葡萄糖的0.5%辛可卡因或2.5 ml含8%葡萄糖的0.5%布比卡因。两组起效时间均很快，感觉阻滞最高平面分布在T1 - T6。布比卡因组镇痛效果更好，尽管感觉和运动阻滞持续时间均短于辛可卡因组。两组在并发症的发生率和严重程度以及新生儿情况方面均无显著差异。整个试验中低血压的高发生率（50 - 65%）及通常较严重的程度，证实了1500 ml晶体预负荷作为预防低血压单一措施的无效性。
