Cummings G C, Bamber D B, Edstrom H H, Rubin A P
Br J Anaesth. 1984 Jun;56(6):573-9. doi: 10.1093/bja/56.6.573.
Subarachnoid anaesthesia was induced in 40 patients with 0.5% bupivacaine 3 ml with no glucose, 5% glucose or 8% glucose, or with hyperbaric cinchocaine . The injections were made in the lateral position and the patients turned supine immediately. The onset, extent and duration of sensory and motor blockade, the quality of anaesthesia, cardiovascular effects, and the frequency of side-effects were studied. The hyperbaric solutions produced a greater cephalad spread (T6-T7) than the glucose-free solution (T10-T11). Cinchocaine produced a longer duration of action at T10 and T12 than the hyperbaric bupivacaine solutions. No advantage was seen when 8% rather than 5% glucose was used. The glucose-free bupivacaine produced intense blockade of long duration and was suitable when a lower level of blockade was adequate for the proposed surgery.
对40例患者进行蛛网膜下腔麻醉，分别注射不含葡萄糖、含5%葡萄糖或8%葡萄糖的0.5%布比卡因3毫升，或注射重比重辛可卡因。注射时患者取侧卧位，注射后立即转为仰卧位。研究感觉和运动阻滞的起效、范围和持续时间、麻醉质量、心血管效应以及副作用发生频率。重比重溶液比不含葡萄糖的溶液产生更高平面的阻滞（T6 - T7对比T10 - T11）。在T10和T12节段，辛可卡因的作用持续时间比重比重布比卡因溶液更长。使用8%葡萄糖而非5%葡萄糖未见优势。不含葡萄糖的布比卡因产生强烈且持续时间长的阻滞，适用于拟行手术所需阻滞平面较低的情况。
