Department of Conservative Dentistry and Endodontics, University of Cagliari, Cagliari, Italy.
Department of Conservative Dentistry and Endodontics, University of Cagliari, Cagliari, Italy.
J Endod. 2021 May;47(5):711-720. doi: 10.1016/j.joen.2021.01.008. Epub 2021 Feb 4.
Proresolving lipid mediators are specialized molecules (SPMs) involved in the active resolution of the inflammatory process by regulating tissue homeostasis. The aim of this study was to investigate the scientific literature to assess the potential of SPMs as an adjunct in the treatment of endodontic infection.
Three electronic databases (PubMed, Web of Science, and Scopus) were searched from their inception until February 2020 (PROSPERO CRD42020164743). Supplemental research was performed by screening the references of the relevant studies eligible for inclusion. A quality assessment of animal studies was performed using the Animal Research: Reporting of In Vivo Experiments guidelines, whereas the Systematic Review Centre for Laboratory animal Experimentation Risk of Bias tool was used to assess the risk of bias.
A total of 3295 records were screened, and 8 articles meeting the criteria were included for this qualitative review. The eligible studies showed a high to moderate overall quality and a low to moderate risk of bias. SPMs positively affected the development of pulpitis and apical periodontitis in experimental animal models. The early treatment of pulpitis with the topical application of SPMs was beneficial to control inflammation within 24 hours from contamination. In addition, SPMs delivered within the root canals after disinfection were found effective in promoting periapical healing.
Our findings suggest that SPMs may play a role in the inception and treatment of pulpal-periapical diseases, and they should be considered for future research for developing new therapeutics as an adjunct to endodontic treatment.
促炎消退脂质介质是参与炎症过程积极消退的特殊分子 (SPM)，通过调节组织稳态发挥作用。本研究旨在通过评估 SPM 作为牙髓感染辅助治疗的潜力，对相关科学文献进行评估。
从建库起至 2020 年 2 月，通过 3 个电子数据库（PubMed、Web of Science 和 Scopus）检索相关文献（PROSPERO CRD42020164743）。通过筛选纳入研究的参考文献进行补充研究。采用动物实验报告中的动物研究（in vivo experiments）指南对动物研究进行质量评估，采用系统评价中心实验室动物实验偏倚风险工具（Systematic Review Centre for Laboratory animal Experimentation Risk of Bias tool）评估偏倚风险。
共筛选出 3295 条记录，符合纳入标准的 8 篇文章进行定性综述。合格研究显示出较高至中等的整体质量和较低至中等的偏倚风险。SPM 可积极影响实验动物模型中牙髓炎和根尖周炎的发展。早期通过局部应用 SPM 治疗牙髓炎可在污染后 24 小时内控制炎症。此外，在消毒后根管内给药 SPM 有助于促进根尖周愈合。
我们的研究结果表明 SPM 可能在牙髓根尖疾病的发生和治疗中发挥作用，应作为牙髓治疗的辅助手段，进一步开展新疗法的研究。
