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肝素结合膨化聚四氟乙烯移植物在肾动脉重建中的应用。

Use of Heparin-Bonded Expanded Polytetrafluoroethylene Grafts for Renal Artery Reconstruction.

机构信息

Department of Vascular Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura-shi, Ibaraki, Japan.

Department of Vascular Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura-shi, Ibaraki, Japan.

出版信息

Ann Vasc Surg. 2021 Jul;74:287-293. doi: 10.1016/j.avsg.2020.12.037. Epub 2021 Feb 4.

DOI:10.1016/j.avsg.2020.12.037
PMID:33548401
Abstract

BACKGROUND

The purpose of this study was to analyze our initial experience in renal artery reconstruction with heparin-bonded expanded polytetrafluoroethylene (ePTFE) grafts.

METHODS

The authors retrospectively reviewed the data of consecutive patients who received open renal reconstruction with a heparin-bonded ePTFE graft at our institution between January 2014 and December 2019.

RESULTS

A total of 22 renal reconstructions with a heparin-bonded ePTFE graft were performed in 17 consecutive patients. In all cases, renal reconstruction was a concomitant procedure during surgical or endovascular aortic procedures. Postoperative complications within 30 days were observed in 9 (53%) patients, including acute kidney injury (n = 6), pneumonia (n = 1), retrograde type B aortic dissection (n = 1), and lower limb ischemia (n = 1). The 30-day mortality rate was 0%. In a median follow-up period of 32 (19-39) months, all grafts were patent without re-intervention. Six patients with preoperative stage 2 chronic kidney disease progressed to stage 3 during follow-up. No patient required temporary or permanent hemodialysis. One patient died from intestinal ischemia at 23 months after surgery.

CONCLUSIONS

This study showed that the patency after open renal reconstruction with a heparin-bonded ePTFE graft was excellent, with acceptable renal outcomes, and demonstrates its safety as a concomitant procedure during an aortic procedure. Heparin-bonded ePTFE grafts are a feasible and effective choice for open renal reconstruction in contemporary practice.

摘要

背景

本研究旨在分析我们使用肝素结合膨胀聚四氟乙烯(ePTFE)移植物进行肾动脉重建的初步经验。

方法

作者回顾性分析了 2014 年 1 月至 2019 年 12 月期间在我院接受开放肾重建术的连续患者的资料,这些患者接受了肝素结合 ePTFE 移植物。

结果

17 例连续患者共进行了 22 例肾重建术,均为手术或血管内主动脉手术的伴随手术。术后 30 天内观察到 9 例(53%)患者出现术后并发症,包括急性肾损伤(n=6)、肺炎(n=1)、逆行型 B 型主动脉夹层(n=1)和下肢缺血(n=1)。30 天死亡率为 0%。中位随访 32(19-39)个月,所有移植物均未再干预且通畅。6 例术前慢性肾脏病 2 期患者在随访期间进展为 3 期。无患者需要临时或永久性血液透析。1 例患者术后 23 个月死于肠缺血。

结论

本研究表明,肝素结合 ePTFE 移植物开放肾重建术后通畅性良好,肾脏结局可接受,且在主动脉手术中作为伴随手术具有安全性。肝素结合 ePTFE 移植物是当代开放肾重建的一种可行有效的选择。

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