Institute of Meterial Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu 610060, PR China.
Brain Behav Immun. 2021 Mar;93:264-276. doi: 10.1016/j.bbi.2021.01.028. Epub 2021 Feb 4.
Meningeal immunity refers to immune surveillance and immune defense in the meningeal immune compartment, which depends on the unique position, structural composition of the meninges and functional characteristics of the meningeal immune cells. Recent research advances in meningeal immunity have demonstrated many new ways in which a sophisticated immune landscape affects central nervous system (CNS) function under physiological or pathological conditions. The proper function of the meningeal compartment might protect the CNS from pathogens or contribute to neurological disorders. Since the concept of meningeal immunity, especially the meningeal lymphatic system and the glymphatic system, is relatively new, we will provide a general review of the meninges' basic structural elements, organization, regulation, and functions with regards to meningeal immunity. At the same time, we will emphasize recent evidence for the role of meningeal immunity in neurodegenerative diseases. More importantly, we will speculate about the feasibility of the meningeal immune region as a drug target to provide some insights for future research of meningeal immunity.
脑膜免疫是指脑膜免疫隔室中的免疫监视和免疫防御，这取决于脑膜的独特位置、结构组成和脑膜免疫细胞的功能特征。脑膜免疫的最新研究进展表明，在生理或病理条件下，复杂的免疫景观有许多新的方式影响中枢神经系统（CNS）的功能。脑膜隔室的正常功能可以保护中枢神经系统免受病原体的侵害，或有助于神经系统疾病的发生。由于脑膜免疫的概念，特别是脑膜淋巴管系统和神经胶质淋巴系统，相对较新，我们将提供一个关于脑膜基本结构元素、组织、调节和功能的概述，涉及脑膜免疫。同时，我们将强调脑膜免疫在神经退行性疾病中的作用的最新证据。更重要的是，我们将推测脑膜免疫区作为药物靶点的可行性，为脑膜免疫的未来研究提供一些见解。
