Gerontology Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium; Frailty in Ageing (FRIA) Research Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Gerontology Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium; Frailty in Ageing (FRIA) Research Department, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium; Department of Geriatrics, Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, B-1090, Brussels, Belgium.
Ageing Res Rev. 2021 May;67:101261. doi: 10.1016/j.arr.2021.101261. Epub 2021 Feb 3.
Fatigue is a common complaint among older adults. Evidence grows that fatigue is linked to several negative health outcomes. A general overview of fatigue and its relationship with negative health outcomes still lacks in the existing literature. This brings complications for healthcare professionals and researchers to identify fatigue-related health risks. Therefore, this study gives an overview of the prospective predictive value of the main negative health outcomes for fatigue in community-dwelling older adults.
PubMed, Web of Knowledge and PsycINFO were systematically screened for prospective studies regarding the relationship between fatigue and negative health outcomes resulting in 4595 articles (last search 5th March 2020). Meta-analyses were conducted in RevMan using Odds ratios (ORs), Hazard ratios (HRs) and relative risk ratios (RR) that were extracted from the included studies. Subgroup-analyses were performed based on (1) gender (male/female), (2) length of follow-up and (3) fatigue level (low, medium and high).
In total, thirty articles were included for this systematic review and meta-analysis encompassing 152 711 participants (age range 40-98 years), providing information on the relationship between fatigue and health outcomes. The results showed that fatigue is related to an increased risk for the occurrence of all studied health outcomes (range OR 1.299-3.094; HR/RR 1.038-1.471); for example, mortality OR 2.14 [1.74-2.63]; HR/RR 1.44 [1.28-1.62]), the development of disabilities in basic activities of daily living (OR 3.22 [2.05-5.38]), or the occurrence of physical decline (OR 1.42 [1.29-1.57]).
Overall fatigue increases the risk for developing negative health outcomes. The analyses presented in this study show that fatigue related physical decline occurs earlier than hospitalization, diseases and mortality, suggesting the importance of early interventions.
疲劳是老年人常见的抱怨。越来越多的证据表明，疲劳与许多负面健康结果有关。然而，在现有文献中，仍然缺乏对疲劳的全面概述及其与负面健康结果的关系。这给医疗保健专业人员和研究人员带来了困难，难以确定与疲劳相关的健康风险。因此，本研究概述了社区居住的老年人中疲劳与主要负面健康结果之间的前瞻性预测价值。
系统检索了 PubMed、Web of Knowledge 和 PsycINFO 中关于疲劳与负面健康结果之间关系的前瞻性研究，共检索到 4595 篇文章（最后一次检索时间为 2020 年 3 月 5 日）。使用从纳入研究中提取的比值比（OR）、风险比（HR）和相对风险比（RR），在 RevMan 中进行了荟萃分析。亚组分析基于（1）性别（男性/女性）、（2）随访时间和（3）疲劳水平（低、中、高）进行。
本系统综述和荟萃分析共纳入 30 篇文章，共纳入 152711 名参与者（年龄 40-98 岁），提供了疲劳与健康结果之间关系的信息。结果表明，疲劳与所有研究的健康结果发生风险增加有关（范围 OR 1.299-3.094；HR/RR 1.038-1.471）；例如，死亡率 OR 2.14 [1.74-2.63]；HR/RR 1.44 [1.28-1.62]）、基本日常生活活动能力下降的残疾发生率（OR 3.22 [2.05-5.38]）或身体功能下降的发生率（OR 1.42 [1.29-1.57]）。
总的来说，疲劳会增加发生负面健康结果的风险。本研究中的分析表明，与疲劳相关的身体功能下降比住院、疾病和死亡发生得更早，这表明早期干预的重要性。
