Rahima A, Bruce N W
Department of Anatomy and Human Biology, University of Western Australia, Nedlands.
Anat Rec. 1988 Feb;220(2):208-11. doi: 10.1002/ar.1092200212.
Unilateral ovariectomy was carried out on rats either 8 days after mating (ULO-A) or 4-6 weeks before mating (ULO-B) and the effects on fetal and placental weights were examined at days 13, 16, and 22 of gestation. ULO-A caused initial fetal and placental hypotrophy at day 13, but thereafter placental weights increased to 123% and 132% of control values at days 16 and 22, respectively. Fetal weights were also 9% heavier in the ULO-A rats at day 22. The ULO-B stimulus resulted in placental but not fetal hypotrophy at day 13 and placental hypertrophy at days 16 and 22. Although the results of the two stimuli were generally similar, it is argued that the mechanisms underlying the ULO-A results were primarily endocrinological whereas those for the ULO-B results were due to crowding of conceptuses in one uterine horn and the subsequent compensatory responses.
在大鼠交配后8天（ULO-A组）或交配前4 - 6周（ULO-B组）进行单侧卵巢切除术，并在妊娠第13、16和22天检查对胎儿和胎盘重量的影响。ULO-A组在第13天导致胎儿和胎盘最初发育迟缓，但此后胎盘重量在第16天和22天分别增加至对照值的123%和132%。在第22天，ULO-A组大鼠的胎儿体重也比对照组重9%。ULO-B组在第13天导致胎盘发育迟缓但未影响胎儿，而在第16天和22天出现胎盘肥大。尽管两种刺激的结果总体相似，但有人认为，ULO-A组结果的潜在机制主要是内分泌性的，而ULO-B组结果的机制是由于一个子宫角内的胚胎拥挤以及随后的代偿反应。
